The title compound (systematic name: [2-butyl-4-chloro-1-[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-yl]methanol), C(41)H(37)ClN(6)O, crystallizes in the centrosymmetric space group P-1 with two independent molecules in the asymmetric unit. These molecules differ significantly only in the relative orientations of the rings in the biphenylyltetrazole moieties. One of the molecules shows disorder for three C atoms in the n-butyl group. Hydrogen bonds link the molecules in an infinite chain along the a axis.
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http://dx.doi.org/10.1107/S0108270104024096 | DOI Listing |
J Labelled Comp Radiopharm
March 2023
Laboratoire de Radiochimie et Cyclotron, Centre de Recherche du CHUM, Montréal, Québec, Canada.
Angiotensin II type 1 receptors (AT R) blocker losartan is used in patients with renal and cardiovascular diseases. [ F]fluoropyridine-losartan has shown favorable binding profile for quantitative renal PET imaging of AT R with selective binding in rats and pigs, low interference of radiometabolites and appropriate dosimetry for clinical translation. A new approach was developed to produce [ F]fluoropyridine-losartan in very high molar activity.
View Article and Find Full Text PDFActa Crystallogr C
November 2004
Institute of General and Ecological Chemistry, Technical University of Łódź, Zeromskiego 116, 90-924 Łódź, Poland.
The title compound (systematic name: [2-butyl-4-chloro-1-[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-yl]methanol), C(41)H(37)ClN(6)O, crystallizes in the centrosymmetric space group P-1 with two independent molecules in the asymmetric unit. These molecules differ significantly only in the relative orientations of the rings in the biphenylyltetrazole moieties. One of the molecules shows disorder for three C atoms in the n-butyl group.
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