Biological processes such as transcription are expected to generate local variations in DNA supercoiling. The existence of localized supercoiling was recently demonstrated in Escherichia coli by using the supercoil-driven B-to-Z transition as a superhelicity probe. This new methodology is described and its extension to other biological systems discussed.
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| http://dx.doi.org/10.1111/j.1365-2958.1992.tb01502.x | DOI Listing |
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