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- The study investigates the long-term effects of multiple myeloma and its treatment on the immune system of cancer survivors, finding significant changes even years after being cancer-free.
- Analysis revealed that these survivors have a compromised bone marrow environment, which is linked to ongoing inflammation and the presence of residual myeloma cells, despite the absence of detectable cancer.
- The research suggests that initial cancer treatment leads to lasting "immunological scarring," indicating that some immune system changes may be irreversible.
Atolls are globally important sites for tropical seabirds.
Nat Ecol Evol
October 2024
School of Biological Sciences, University of Auckland, Auckland, New Zealand.
Seabirds play critical roles on islands. By catalysing terrestrial and marine productivity through guano nutrient input, seabirds support natural island functioning. In the Indo-Pacific, atolls comprise one-third of all islands but only ~0.
View Article and Find Full Text PDFExploring Potential Ethnic Bias Among MMPI-3 Scales in Assessing Personality Psychopathology.
Assessment
May 2024
Sam Houston State University, Huntsville, TX, USA.
This study examined statistical bias in the measurement of personality psychopathology in the Latinx population using the Minnesota Multiphasic Personality Inventory-3 (MMPI-3). Data were extracted from two studies that yielded a composite data set of 103 White individuals and 250 Latinx individuals. All participants were administered the MMPI-2-Restructured Form-Extended Battery (MMPI-2-RF-EX) or MMPI-3 and the Personality Inventory for the -5 Short Form (PID-5-SF).
View Article and Find Full Text PDFGasdermin D drives focal crystalline thrombotic microangiopathy by accelerating immunothrombosis and necroinflammation.
Blood
July 2024
Renal Division, Department of Medicine IV, Ludwig Maximilian University Hospital, Ludwig Maximilian University, Munich, Germany.
Thrombotic microangiopathy (TMA) is characterized by immunothrombosis and life-threatening organ failure but the precise underlying mechanism driving its pathogenesis remains elusive. In this study, we hypothesized that gasdermin D (GSDMD), a pore-forming protein that serves as the final downstream effector of the pyroptosis/interleukin-1β (IL-1β) pathway, contributes to TMA and its consequences by amplifying neutrophil maturation and subsequent necrosis. Using a murine model of focal crystalline TMA, we found that Gsdmd deficiency ameliorated immunothrombosis, acute tissue injury, and failure.
View Article and Find Full Text PDFManagement of adult patients with podocytopathies: an update from the ERA Immunonephrology Working Group.
Nephrol Dial Transplant
March 2024
Department of Internal Medicine IV, Nephrology and Hypertension, Medical University Innsbruck, Innsbruck, Austria.
The histopathological lesions, minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are entities without immune complex deposits which can cause podocyte injury, thus are frequently grouped under the umbrella of podocytopathies. Whether MCD and FSGS may represent a spectrum of the same disease remains a matter of conjecture. Both frequently require repeated high-dose glucocorticoid therapy with alternative immunosuppressive treatments reserved for relapsing or resistant cases and response rates are variable.
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