Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Development of a prediction model based on Hemoglobin, Albumin, Lymphocyte count, and Platelet-score for lymph node metastasis in rectal cancer.
Eur J Cancer Prev
January 2025
Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.
This study aimed to evaluate the ability of the preoperative Hemoglobin, Albumin, Lymphocyte count, and Platelet (HALP) score to predict lymph node metastasis (LNM) in patients with rectal cancer (RC) and improve prediction accuracy by incorporating clinical parameters. Data from 263 patients with RC were analyzed. The receiver operating characteristic (ROC) curve was used to determine the optimal cutoff value (OCV) for the HALP score in predicting LNM.
View Article and Find Full Text PDFTherapeutic effects of platelet-derived extracellular vesicles on viral myocarditis correlate with biomolecular content.
Front Immunol
January 2025
Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Introduction: Extracellular vesicles (EVs) can potently inhibit inflammation yet there is a lack of understanding about the impact of donor characteristics on the efficacy of EVs. The goal of this study was to determine whether the sex and age of donor platelet-derived EVs (PEV) affected their ability to inhibit viral myocarditis.
Methods: PEV, isolated from men and women of all ages, was compared to PEV obtained from women under 50 years of age, which we termed premenopausal PEV (pmPEV).
Construction of an Interpretable Model of the Risk of Post-Traumatic Brain Infarction Based on Machine Learning Algorithms: A Retrospective Study.
J Multidiscip Healthc
January 2025
Department of Neurosurgery, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People's Republic of China.
Background: Post-traumatic cerebral infarction (PTCI) is a severe complication resulting from traumatic brain injury (TBI), which can lead to permanent neurological damage or death. The investigation of the factors associated with PTCI and the establishment of predictive models are crucial for clinical practice.
Methods: We made a retrospective analysis of clinical data from 1484 TBI patients admitted to the Neurosurgery Department of a provincial hospital from January 2018 to December 2023.
Synthesis and Investigation of Peptide-Drug Conjugates Comprising Camptothecin and a Human Protein-Derived Cell-Penetrating Peptide.
Chem Biol Drug Des
January 2025
Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Drug targeting strategies, such as peptide-drug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs. Here we investigated the ability of PDCs comprising a human protein-derived cell-penetrating peptide-platelet factor 4-derived internalization peptide (PDIP)-as a targeting strategy to improve the selectivity of camptothecin (CPT), a topoisomerase I inhibitor that suffers from off-target toxicity. The intranuclear target of CPT allowed exploration of PDC design features required for optimal potency.
View Article and Find Full Text PDFTrajectories of platelet indices and their association with mortality in the ICU-a longitudinal cohort study.
Scand J Clin Lab Invest
January 2025
School of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
While thrombocytopenia's link to mortality is known, the prognostic impact of longitudinal trajectories of platelet indices in combination with analysis of thrombocytopenia's mediating role remains unexplored. This is the first study that addresses this significant gap by investigating the association between seven platelet indices trajectory subphenotypes and ICU mortality, considering thrombocytopenia's mediating influence. Four hundred and twenty-one adult ICU patients were enrolled in this longitudinal cohort study.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!