Abstract Quadrupled hamstring tendon is one of the most commonly used ligamentous substitutes in anterior cruciate ligament reconstruction. We describe a case of a young athlete who sustained a rerupture of a semitendinosus-gracilis autograft fixed with biodegradable screws 2 years after primary surgery. Radiologic, arthroscopic, histologic, and electromicroscopic investigation showed tendon-to-bone healing of the soft tissue graft and partial degradation of the interference screws.
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http://dx.doi.org/10.1016/j.arthro.2004.08.007 | DOI Listing |
Acc Mater Res
December 2024
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States.
As a ubiquitous feature of the biological world, gradation, in either composition or structure, is essential to many functions and processes. Taking protein gradation as an example, it plays a pivotal role in the development and evolution of human bodies, including stimulation and direction of the outgrowth of peripheral nerves in a developing fetus. It is also critically involved in wound healing by attracting and guiding immune cells to the site of injury or infection.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
December 2024
Department of Orthopedic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. Electronic address:
Background: Although older adult patients have a higher retear rate after rotator cuff (RC) repair, the influence of aging on the healing process remains unclear. During mouse enthesis development, a multipotent progenitor co-expressing scleraxis (Scx) and SRY-box 9 (Sox9) contributes to enthesis formation. Scx/Sox9 cells may act as enthesis progenitors even during postnatal healing, and their number decreases with maturation.
View Article and Find Full Text PDFArthroscopy
November 2024
Rochester, Minnesota.
Aging is associated with increased pathology in musculoskeletal tissues. Aging results in the accumulation of senescent cells, stem cell exhaustion, sterile inflammation, and immune cell dysfunction systemically and locally. Improving healing and regeneration during musculoskeletal aging is a significant area of clinical need.
View Article and Find Full Text PDFOrthop J Sports Med
November 2024
OrthoCarolina and Atrium Health Musculoskeletal Institute, Charlotte, North Carolina, USA.
Background: The use of all-suture anchors (ASAs) for onlay patellar and femoral fixation of medial patellofemoral ligament (MPFL) grafts may provide clinical benefit, particularly in the small or pediatric knee; however, biomechanical data supporting the use of ASAs are lacking.
Purpose/hypothesis: The purpose of this study was to compare ASAs to larger interference implants for MPFL reconstruction in a time-zero biomechanical model. It was hypothesized that ASAs would have comparable cyclic elongation to interference fixation and would exceed published biomechanical values for the native human MPFL.
Adv Healthc Mater
November 2024
Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Rotator cuff injuries often necessitate surgical intervention, but the outcomes are often unsatisfactory. The underlying reasons can be attributed to multiple factors, with the intricate inflammatory activities and insufficient presence of stem cells being particularly significant. In this study, an innovative inflammation-responsive core-shell micro-hydrogel is designed for independent release of SDF-1 and IL-4 within a single delivery system to promote tendon-to-bone healing by recruiting MSCs and modulating M2 macrophages polarization.
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