Doubly quantized vortices were topologically imprinted in /F=1> 23Na condensates, and their time evolution was observed using a tomographic imaging technique. The decay into two singly quantized vortices was characterized and attributed to dynamical instability. The time scale of the splitting process was found to be longer at higher atom density.
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http://dx.doi.org/10.1103/PhysRevLett.93.160406 | DOI Listing |
Biophys J
January 2025
Department of Pharmacology, University of California Davis, California 95616.
In every heartbeat, cardiac muscle cells perform excitation-Ca signaling-contraction (EC) coupling to pump blood against the vascular resistance. Cardiomyocytes can sense the mechanical load and activate mechano-chemo-transduction (MCT) mechanism, which provides feedback regulation of EC coupling. MCT feedback is important for the heart to upregulate contraction in response to increased load to maintain cardiac output.
View Article and Find Full Text PDFBiophys J
January 2025
Department of Chemistry, Chicago Center for Theoretical Chemistry, The James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, United States. Electronic address:
Microtubules (MTs) constitute the largest components of the eukaryotic cytoskeleton and play crucial roles in various cellular processes, including mitosis and intracellular transport. The property allowing MTs to cater to such diverse roles is attributed to dynamic instability, which is coupled to the hydrolysis of GTP (guanosine-5'-triphosphate) to GDP (guanosine-5'-diphosphate) within the β-tubulin monomers. Understanding the equilibrium dynamics and the structural features of both GDP- and GTP-complexed MT tips, especially at an all-atom level, remains challenging for both experimental and computational methods because of their dynamic nature and the prohibitive computational demands of simulating large, many-protein systems.
View Article and Find Full Text PDFNat Commun
January 2025
Chimie du Solide et de l'Énergie, UMR 8260, Collège de France, Paris, France.
As batteries drive the transition to electrified transportation and energy systems, ensuring their quality, reliability, lifetime, and safety is crucial. While the solid electrolyte interphase (SEI) is known to govern these performance characteristics, its dynamic nature makes understanding its nucleation, growth, and composition an ambitious, yet elusive aspiration. This work employs chalcogenide fibres embedded in negative electrode materials for operando Infra-red Fibre-optic Evanescent Wave Spectroscopy (IR-FEWS), combined with Multivariate Curve Resolution by Alternating Least Squares (MCR-ALS) algorithms for spectra analysis.
View Article and Find Full Text PDFJ Biotechnol
January 2025
Johns Hopkins Biomedical Engineering; Johns Hopkins University Department of Molecular Biology and Genetics, Baltimore, Maryland, USA; Johns Hopkins University Department of Medicine, Division of Infectious Disease, Baltimore, Maryland, USA. Electronic address:
Chinese Hamster Ovary (CHO) cells produce monoclonal antibodies and other biotherapeutics at industrial scale. Despite their ubiquitous nature in the biopharmaceutical industry, little is known about the behaviors of individual transfected clonal CHO cells. Most CHO cells are assessed on their stability, their ability to produce the protein of interest over time.
View Article and Find Full Text PDFHum Mov Sci
January 2025
Joint Department of Biomedical Engineering, UNC Chapel Hill & NC State University, Chapel Hill, NC, USA. Electronic address:
Straight line walking currently dominates research into mechanisms associated with walking-related instability; however, the dynamics of everyday walking behavior are far more complex. The figure-8 walk test (F8W) is a clinically-feasible activity that focuses on turning mobility and provides a convenient and relevant task for understanding age-related differences in walking beyond our present knowledge of steady-state behavior. Our purpose was to investigate the effects of age (n = 30 older versus n = 31 younger adults) on path characteristics and the "smoothness" of turning mobility - herein measured via normalized center of mass jerk - during the F8W.
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