Objectives: To develop an immune-competent animal model for mucosally derived squamous cell carcinoma (SCCA).
Study Design: Fifteen Fischer 344 rats were inoculated with 1, 2, 5, 10, or 20 x 10(6) FAT7 cells in their flanks. The animals were observed for tumor growth and metastasis.
Results: All animals developed tumors that grew exponentially. Pulmonary metastases developed in all animals and 13% developed lymph node metastases.
Conclusion: The FAT7 flank tumor in Fischer 344 rats is a new animal model that closely resembles the behavior of human mucosal head and neck cancer.
Significance: The existence of an immune-competent, mucosally derived, and reliable animal model of SCCA that somewhat resembles human head and neck SCCA gives the opportunity to perform immune-modulating experiments on head and neck cancer in these animals.
Ebm Rating: B-3.
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| http://dx.doi.org/10.1016/j.otohns.2004.01.014 | DOI Listing |
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