Earlier we have shown that the epidermal growth factor receptor was unable to retain its phospho Tyr signal after the assembly of staphylococcal alpha-hemolysin (alpha-HL). However, the nature of the protein tyrosine phosphatase (PTPase) or its identity is not known. In this report, we demonstrate that the alpha-HL elevates the activity of receptor like protein tyrosine phosphatase sigma (rPTPsigma). The alpha-HL induced dephosphorylation is prominent only in intact A431 cells. The PTPase activity is not inhibited if the alpha-HL treatment precedes PTPase inhibitor treatments. The anti-EGFr immunoprecipitates have exhibited higher PTPase activity after alpha-HL treatment of A431 cells. Interestingly, PTPase activity of anti-EGFr immunoprecipitates from the A431 cells expressing the antisense message of rPTPsigma has not increased despite alpha-HL treatment, confirming the role of rPTPsigma in the dephosphorylation of EGFr. The studies presented here will be useful in understanding the process of signal modulation by the assembly of alpha-HL.
Effective treatment of squamous cell carcinoma (SCC) poses challenges due to intrinsic drug resistance and limited drug penetration into tumor cells. Nanoparticle-based drug delivery systems have emerged as a promising approach to enhance therapeutic efficacy; however, they often face hurdles such as inadequate cellular uptake and rapid lysosomal degradation. This study explores the potential of iontophoresis to augment the efficacy of liposome and immunoliposome-based drug delivery systems for SCC treatment.
Cutaneous squamous cell carcinoma (cSCC) is a common type of cutaneous cancer globally. M2 macrophage-derived exosomes (M2 exosomes) facilitate the development of cancer. Ferroptosis, a newly uncovered form of cell death, is linked to cancer progression.
Introduction: Cancer has emerged as one of the leading causes of fatality all over the world. Phytoconstituents are being studied for their synergistic effects, which include disease prevention by altering molecular pathways and immunomodulation without side effects. The present experiment aims to explore the cancer preventive activities of Linn leaves extract in skin cancer cell lines (A431) and colon cancer cell lines (COLO 320DM)).
The current study proposes the in vitro and in silico anticancer evaluation of clove ( L.) essential oil (CEO). The steam hydrodistillation method used yielded 10.
Sun persuades excess ROS production in the skin, altering pro-inflammatory factors and cellular responses, thereby contributing to the progression of skin disorders and skin cancer. In this study, the non-animal, and methods have been employed to interpret the potential of bioactive mangiferin against skin inflammation and skin cancer. In the approach, auto blind docking tool CB Dock 2 was utilized to assess and compare the efficacy of mangiferin against some conventional drugs like aspirin, diclofenac, betamethasone for inflammation and with 5-fluorouracil, docetaxel, doxorubicin, imiquimod, paclitaxel, sonidegib, vincristine and vismodegib for skin cancer.
