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Congenital Pulmonary Airway Malformations With a Reconsideration and Current Perspective on the Stocker Classification.
Pediatr Dev Pathol
June 2023
Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children's Hospital, Washington University Medical Center, St. Louis, MO, USA.
Congenital cystic pulmonary lesions (CCPLs) are represented by the following entities: congenital pulmonary airway malformation (CPAM), formerly congenital cystic adenomatoid malformation, extra- and intralobar sequestration (EIS), congenital lobar emphysema (overexpansion), and bronchogenic cyst. The developmental model of CPAM histogenesis by Stocker proposed perturbations designated as CPAM type 0 to type 4 without known or specific pathogenetic mechanisms along the airway from the bronchus to the alveolus. This review highlights mutational events either at the somatic level in KRAS (CPAM types 1 and possibly 3) or germline variants in congenital acinar dysplasia, formerly CPAM type 0, and pleuropulmonary blastoma (PPB), type I, formerly CPAM type 4.
View Article and Find Full Text PDFNeuroendocrine carcinoma of the breast: A case report and review of the literature.
Int J Surg Case Rep
October 2022
Obstetrics and Gynecology Department, Univesity Hospital Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco.
Introduction: Neuroendocrine carcinomas mainly affect the bronchopulmonary system and the gastrointestinal tract. Mammary localizations are rare. They represent less than 0.
View Article and Find Full Text PDFTherapeutic effects of fibroblast growth factor-10 on hyperoxia-induced bronchopulmonary dysplasia in neonatal mice.
Am J Transl Res
August 2017
Department of Pediatrics, Bayi Children's Hospital of The PLA Army General HospitalBeijing, China.
Article Synopsis
- * Fibroblast growth factor-10 (FGF-10) plays a crucial role in lung development and reduces inflammation in lung conditions, with its expression notably decreased in neonatal mice with BPD.
- * Preliminary studies suggest that FGF-10 not only supports the growth of essential lung cells but also inhibits harmful inflammatory pathways, indicating its potential as a therapeutic strategy for treating BPD in neonates.
[Bronchopulmonary carcinosarcoma].
Rev Med Interne
July 1998
Service de pneumologie, Pavillon Laënnec, Strasbourg, France.
Introduction: Bronchopulmonary carcinosarcoma is an uncommon neoplasm consisting of mixed malignant epithelial and mesenchymal cells.
Exegesis: We report a case of bronchopulmonary carcinosarcoma in a 62-year-old man illustrating some characteristics of this tumor of poor prognosis and unknown histogenesis.
Conclusion: Bronchopulmonary carcinosarcoma has clinical and X rays features identical to those of bronchopulmonary epithelial malignant tumors.
[A benign broncho-pulmonary lesion may hide another. Association of a granular cell tumor and an intrapulmonary lymphatic ganglion].
Rev Mal Respir
April 1994
Service de Pneumologie, Hôpital de Boisguillaume, CHU de Rouen.
The authors record the case of a patient who was under review for pulmonary tuberculosis in whom an Abrikossof granular cell tumour and a cyst were found which had developed from an intrapulmonary lymph node. These two entities are rare and their association extremely unusual and have never been described until now. We review their histogenesis.
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