AI Article Synopsis
- The study observed the prevalence of salivary beta-lactamase activity (SbetaA) in infants and its connection to beta-lactamase-producing bacteria in their saliva.
- At 6 months old, 46% of infants showed SbetaA, with a high correlation between SbetaA positivity and the presence of beta+ bacteria.
- By 12 months, SbetaA was found in 54% of infants, and exposure to antibiotics during infancy increased the likelihood of having SbetaA.
Article Abstract
Beta-lactamase production by oral bacteria is common in infancy and is associated with use of antimicrobial agents in infants. The present longitudinal study aimed to examine the frequency of salivary beta-lactamase activity (SbetaA), to compare SbetaA with the presence of beta-lactamase-producing (beta+) aerobic and anaerobic species in saliva, and to estimate the impact of antimicrobial exposure on the emergence of SbetaA in healthy infants during their first year of life. At 6 months, SbetaA was detected in 46% infants; 89% SbetaA-positive infants and 55% SbetaA-negative infants harboured beta+ species at this time (OR 7.08; CI 1.31-38.34). At 12 months, SbetaA was detected in 54% infants. Exposure to antimicrobials during the first year of life increased the risk (OR 2.60; CI 0.72-9.36) of having SbetaA.
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| http://dx.doi.org/10.1016/j.ijantimicag.2004.06.014 | DOI Listing |
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