AI Article Synopsis

  • The study examined how spreading depression (SD) spreads differently across various cortical regions in rats, focusing on the frontal, parietal, and cingulate cortex.
  • Researchers used a 4 x 4 electrode array and magnetoencephalography to track the patterns of ion movements and brain activity initiated by applying a potassium chloride solution.
  • Results showed that SD began in the lateral cortex and then moved to medial areas, with faster propagation rates in the medial regions, highlighting that the spreading patterns are not uniform across the cortex.

Article Abstract

Spreading depression (SD) propagates in cortical regions that are different in their morphological and functional characteristics. We tested whether the propagation pattern of spreading depression was different between parts of the cortex. In six adult rats, we recorded the ECoG by a 4 x 4 electrode array that covered parts of the frontal, parietal cortex and the cingulate cortex. Simultaneously a 16-channel magnetoencephalogram was recorded to characterize the development and direction of intracortical ion movements accompanying this phenomenon. Spreading depression was initiated by occipital application of 0.3 molar KCl solution. Depolarization was observed, at first, at lateral cortical regions and then at medial cortical regions. Thereafter, the propagation velocity increased in medial cortical regions and was faster than in lateral regions. Negative potential shifts were detected by all electrodes, but the depolarization reached a maximum over lateral and caudal cortical regions. The recorded magnetic fields indicated the same orientation of currents underlying these fields, which was perpendicular to the wave front and points away from the depolarization region. Overall, the data indicated that propagation patterns of spreading depression differed between parts of the cortex and, thus, propagation was inhomogeneous. This propagation was accompanied by strong currents parallel to the cortical surface.

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Source
http://dx.doi.org/10.1016/j.brainres.2004.09.002DOI Listing

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