Background: Amyloidosis of the endometrium is a rare occurrence according to current literature. Previously reported cases have presented with menorrhagia or postmenopausal bleeding.
Case: A postmenopausal woman with multiple medical problems presented with fatigue and weight loss. During the evaluation for her 18-kg weight loss, a computed tomography scan revealed an enlarged uterus and liver lesions. Endometrial and liver biopsies were performed secondary to concern over metastatic cancer, given an enlarged uterus in a postmenopausal woman with liver masses. She was found to have systemic primary amyloidosis in multiple organs, including her endometrium.
Conclusion: This patient represents an interesting case of systemic amyloidosis involving the endometrium that is not associated with vaginal bleeding. The presence of amyloid in the endometrium may be more common than currently recognized, because patients without vaginal bleeding are not routinely evaluated for amyloid deposition in their reproductive organs.
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From the Instituto Nacional de Câncer, Coordenação de Pesquisa, Programa de Oncobiologia Celular e Molecular, Rio de Janeiro, Brazil,
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Departments of *Pathology, Neuroscience, and Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA; Departments of Pathology, Immunology and Microbiology and Population Health & Reproduction, and California Animal Health and Food Safety Laboratory System, University of California, Davis, Davis, California, USA; and INRA, UMR1313 Unité Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France
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Department of Obstetrics and Gynecology, University of South Carolina and Palmetto Richland Memorial Hospital, Columbia, South Carolina, USA.
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