Neuronal communication is dependent on the fusion of 40-50 nm in diameter synaptic vesicles containing neurotransmitters, at the presynaptic membrane. Here we report for the first time at 5-8A resolution, the presence of 8-10 nm in diameter cup-shaped neuronal fusion pores or porosomes at the presynaptic membrane, where synaptic vesicles dock and fuse to release neurotransmitters. The structure, isolation, composition, and functional reconstitution of porosomes present at the nerve terminal are described. These findings reveal the molecular mechanism of neurotransmitter release at the presynaptic membrane of nerve terminals.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cellbi.2004.07.004 | DOI Listing |
Publication Analysis
Top Keywords
presynaptic membrane
12
structure isolation
8
isolation composition
8
neuronal fusion
8
synaptic vesicles
8
composition reconstitution
4
reconstitution neuronal
4
fusion pore
4
pore neuronal
4
neuronal communication
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!