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Annual Research Review: Micronutrients and their role in the treatment of paediatric mental illness.
J Child Psychol Psychiatry
December 2024
Department of Psychiatry, Center for Mental Health Innovation, Oregon Health Science University, Portland, Oregon, USA.
The aim of this narrative review is to summarize evidence relating the importance of nutrient intake from diet and supplementation for paediatric mental health. We begin by reviewing several mechanisms by which nutrients maximize brain health, including enabling metabolic reactions to occur, supporting mitochondrial function, reducing inflammation and assisting with detoxification. Circumstances that may contribute to an individual requiring additional nutrients beyond what are available in the diet, such as consumption of nutritionally depleted food, individual differences in biological need, long-term medication use and gut-brain health needs are then reviewed.
View Article and Find Full Text PDFHow will developmental neuroimaging contribute to the prediction of neurodevelopmental or psychiatric disorders? Challenges and opportunities.
Dev Cogn Neurosci
December 2024
Treuman Katz Center for Pediatric Bioethics and Palliative Care, Seattle Children's Research Institute, USA; Department of Pediatrics, University of Washington School of Medicine, USA. Electronic address:
Successful developmental neuroimaging efforts require interdisciplinary expertise to ground scientific questions in knowledge of human development, modify and create technologies and data processing pipelines suited to the young brain, and ensure research procedures meet the needs and protect the interests of young children and their caregivers. This paper brings together four interdisciplinary perspectives to tackle a set of questions that are central for the field to address as we imagine a future role for developmental neuroimaging in the prediction of neurodevelopmental or psychiatric disorders: 1) How do we generate a strong evidence base for causality and clinical relevance? 2) How do we ensure the integrity of the data and support fair and wide access? 3) How can these technologies be implemented in the clinic? 4) What are the ethical obligations for neuroimaging researchers working with infants and young children?
View Article and Find Full Text PDFTumor-derived G-CSF induces an immunosuppressive microenvironment in an osteosarcoma model, reducing response to CAR.GD2 T-cells.
J Hematol Oncol
December 2024
Department of Onco-Haematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, San Paolo N°15 Street, 00146, Rome, Italy.
Sarcomas are rare, mesenchymal tumors, representing about 10-15% of all childhood cancers. GD2 is a suitable target for chimeric antigen receptor (CAR) T-cell therapy due to its overexpression in several solid tumors. In this preclinical study, we investigated the potential use of iCasp9.
View Article and Find Full Text PDFChallenges in Toileting Evaluation and Interventions for Children With Cerebral Palsy: A Delphi Study.
Am J Occup Ther
January 2025
Malahat Akbarfahimi, PhD, is Professor of Cognitive Neuroscience, Neuroscience Research Center, Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran;
Importance: Toileting difficulties have a significant impact on the daily lives of children with cerebral palsy (CP), yet research on this issue remains inadequate. There is a critical need to better understand the challenges health care professionals face in addressing toileting difficulties.
Objective: To explore challenges faced by health care professionals in toileting evaluation and interventions for children with CP ages 6-18 yr.
Polio outbreaks in the post-COVID-19 pandemic era: causes and solutions.
Pathog Glob Health
December 2024
Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The coronavirus disease 2019 (COVID-19) pandemic has disrupted polio immunization programs worldwide. The consequences of these programs' suspension were not fully presented during the COVID-19 pandemic, as some take time to present in a population. We conducted a narrative review to provide a perspective of current literature on the effect of the COVID-19 pandemic on efforts made for poliomyelitis eradication.
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