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Background: Imaging and plasma markers are used as key indicators of disease for Alzheimer's disease (AD) but their usefulness in predicting regional tau pathology is relatively understudied. Our objective was to construct predictive models for regional tau pathology measured on postmortem brain tissue using multiple ante-mortem AD biomarkers. We focused on hippocampal and parietal regions that were immunostained with AT8 and 2E9 that reflect early and advanced aspects of tangle maturity, respectively.
View Article and Find Full Text PDFBackground: Imaging and plasma markers are used as key indicators of disease for Alzheimer's disease (AD) but their usefulness in predicting regional tau pathology is relatively understudied. Our objective was to construct predictive models for regional tau pathology measured on postmortem brain tissue using multiple ante-mortem AD biomarkers. We focused on hippocampal and parietal regions that were immunostained with AT8 and 2E9 that reflect early and advanced aspects of tangle maturity, respectively.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA.
Background: In recent years, brain banks have become a valuable resource for examining the molecular underpinnings of various neurological and psychological disorders such as Alzheimer's disease and Parkinson's disease; however, the availability of brain tissue has significantly declined. Proper collection, preparation, and preservation of post-mortem autopsy tissue are essential for optimal downstream brain tissue distribution and experimentation. Collaborations between brain banks through larger networks such as NeuroBioBank with centralized sample request mechanisms promote tissue distribution where brain donations are disproportionately lower.
View Article and Find Full Text PDFDo forensic genetic markers disclose more information about us than they should? (A review).
Int J Legal Med
January 2025
Health Legislation, Psychiatry and Pathology Department, Medicine Faculty, The Complutense University of Madrid, Madrid, Spain.
The 20 established STRs that make up the CoDIS package must comply with national and international privacy rights and legal policies. Current research reveals that it is possible that certain genetic markers, used in forensic contexts, may show information about other neighboring markers that could reflect certain private characteristics of individuals. Therefore, we will aim to find out, through a literature review, whether there may indeed be associations between some of the STRs alleles established by CoDIS and medical and phenotypic conditions, with the aim of checking whether this problem has a real basis.
View Article and Find Full Text PDFSex Estimation Through Orbital Measurements: A Machine Learning Approach for Forensic Science.
Diagnostics (Basel)
December 2024
Department of Forensic Medicine and Toxicology, School of Medicine, National and Kapodistrian University of Athens, 11 527 Goudi, Greece.
Background: Sex estimation has been extensively investigated due to its importance for forensic science. Several anatomical structures of the human body have been used for this process. The human skull has important landmarks that can serve as reliable sex estimation predictors.
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