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Alternative splicing regulation by tumor suppressing subtransferable candidate 4: a pathway to tumor suppression.
Front Immunol
December 2024
Children's Hospital of Fudan University, National Children's Medical Center, and Shanghai Key Laboratory of Medical Epigenetics, International Colaboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Introduction: RNA splicing is a crucial posttranscriptional process that governs gene expression, and defects in alternative splicing contribute to various diseases, including cancer. Tumor suppressing subtransferable candidate 4 (TSSC4) is a known tumor suppressor and has been identified as part of the U5 small nuclear ribonucleoprotein (snRNP), which is involved in tri-snRNP biogenesis. However, the precise role of TSSC4 in regulating alternative splicing and its impact on tumor growth remain unclear.
View Article and Find Full Text PDFSuppressing GDF15 enhances the chemotherapeutic effect of 5 FU on MSI-H CRC by regulating the ferroptosis pathway SLC7A11/GSH/GPX4.
J Cancer Res Clin Oncol
December 2024
Department of Pathology, Molecular Medicine and Cancer Research Center, Department of Clinical Pathololgy, Laboratory of Pathology Diagnostic Center, Chongqing Medical University, Chongqing, China.
Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor beta (TGF-β) superfamily and is related to metabolism, injury, and aging. GDF15 has both tumor-promoting and tumor-suppressing effects. However, its role in colorectal cancer (CRC) with high microsatellite instability (MSI-H) must be further clarified.
View Article and Find Full Text PDFMolecular dynamics-based computational investigations on the influence of tumor suppressor p53 binding protein against other proteins/peptides.
Sci Rep
December 2024
Immunology Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia.
The tumor-suppressing p-53 binding protein is a crucial protein that is involved in the prevention of cancer via its regulatory effect on a number of cellular processes. Recent evidence indicates that it interacts with a number of other proteins involved in cancer in ways that are not fully understood. An understanding of such interactions could provide insights into novel ways p53 further exerts its tumour prevention role via its interactions with diverse proteins.
View Article and Find Full Text PDFRecent development of nanotechnology-based approaches for gynecologic cancer therapy.
Obstet Gynecol Sci
November 2024
Department of Animal Science & Technology and BET Research Institute, Chung-Ang University, Anseong, Korea.
Article Synopsis
- * Emerging nanotechnology-based therapies, like targeted drug delivery and phototherapies, show promise in addressing the limitations of traditional treatments by improving drug solubility and tumor targeting.
- * This review explores the potential of these innovative nanotechnology approaches to enhance treatment outcomes for patients with gynecologic cancers, offering hope for better management and survival rates.
ANXA6 expression as a potential indicator of tumor diagnosis, metastasis and immunity in nasopharyngeal carcinoma.
Int J Biol Macromol
December 2024
Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China. Electronic address:
This study aimed to explore the potential of ANXA6 as a biomarker and its possible mechanisms, like its expression patterns and clinical significance, as well as exploring its underlying biological functions and regulatory networks in nasopharyngeal carcinoma (NPC). Differentially expressed proteins were identified by proteomics technology. PCR, western blotting, immunohistochemistry, and ELISA analysis of serum were used to analyze ANXA6's clinical role.
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