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The Inaugural Olden Distinguished Lecture: Economic Inequality and Health Disparities.
Environ Health Perspect
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Durham, North Carolina, USA.
Role of research in public health.
Neurotoxicology
December 2020
National Institute of Environmental Health Sciences and National Toxicology Program, USA. Electronic address:
Environmental health research is at a promising stage for more precisely identifying gene-environment components of disease. Simplistic models and reductionist approaches that have been the norm both in toxicology and in clinical medicine are beginning to be replaced with a more holistic or systems biology approach. We are slowly moving to an understanding that the time between an exposure and its consequence as a diagnosed disease is a time during which many different biochemical changes are occurring and a time during which many biomarkers of disease progression could be identified and used.
View Article and Find Full Text PDFAccelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.
Aging (Albany NY)
December 2020
Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Background: Accelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis and thus contribute to sensitivity to environmental exposures.
Methods: Using 497 participants from the CATHGEN cohort, we evaluated whether accelerated epigenetic aging increases cardiovascular sensitivity to traffic-related air pollution (TRAP) exposure. We used residential proximity to major roadways and source apportioned air pollution models as measures of TRAP exposure, and chose peripheral arterial disease (PAD) and blood pressure as outcomes based on previous associations with TRAP.
Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip.
PLoS One
January 2020
National Health and Environmental Effects Laboratory, US Environmental Protection Agency, Chapel Hill, NC, United States of America.
DNA methylation age (DNAm age) has become a widely utilized epigenetic biomarker for the aging process. The Horvath method for determining DNAm age is perhaps the most widely utilized and validated DNA methylation age assessment measure. Horvath DNAm age is calculated based on methylation measurements at 353 loci, present on Illumina's 450k and 27k DNA methylation microarrays.
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