Whole-body-vibration (WBV) exposure levels experienced by transport truck operators were investigated to determine whether operator's exposure exceeded the 1997 International Standards Organization (ISO) 2631-1 WBV guidelines. A second purpose of the study was to determine which truck characteristics predicted the levels of WBV exposures experienced. The predictor variables selected based on previous literature and our transportation consultant group included road condition, truck type, driver experience, truck mileage and seat type. Tests were conducted on four major highways with 5 min random samples taken every 30 min of travel at speeds greater than or equal to 80 km/h (i.e. highway driving). Results indicated operators were not on average at increased risk of adverse health effects from daily exposures when compared to the ISO WBV guidelines. Significant regression models predicting the frequency-weighted RMS accelerations for the x (F((5,97)) = 8.63, p < 0.01), y (F((5,97)) = 7.74, p < 0.01), z (F((5,61)) = 9.83, p < 0.01) axes and the vector sum of the orthogonal axes (F((5,61)) = 13.89, p < 0.01) were observed. Road condition was a significant predictor (p < 0.01) of the frequency-weighted RMS accelerations for all three axes and the vector sum of the axes, as was truck type (p < 0.01) for the z-axis and vector sum. Future research should explore the effects of seasonal driving, larger vehicle age differences, greater variety of seating and suspension systems and team driving situations.
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http://dx.doi.org/10.1080/00140130410001712618 | DOI Listing |
JAMA Netw Open
January 2025
Department of Child and Adolescent Psychiatry-Psychotherapy, University Hospital Ulm, Ulm, Germany.
Importance: Associations between child maltreatment (CM) and health have been studied broadly, but most studies focus on multiplicity (number of experienced subtypes of CM). Studies assessing multiple CM characteristics are scarce, partly due to methodological challenges, and were mostly conducted in patient samples.
Objective: To determine the importance of CM characteristics in association with physical multimorbidity in adulthood for women and men in a German representative sample.
Mol Psychiatry
January 2025
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Modelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms and substance use (prodromal features) over time. Temporal network analysis can detect causal dependence between and within prodromal features by representing prodromal features as nodes, with their connections (edges) indicating the likelihood of one feature preceding the other. In SMD, node centrality could reveal insights into important prodromal features and potential intervention targets.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Machine Learning Group, Technische Universität Berlin, 10587 Berlin, Charlottenburg, Germany.
We introduce the alchemical harmonic approximation (AHA) of the absolute electronic energy for charge-neutral iso-electronic diatomics at fixed interatomic distance d0. To account for variations in distance, we combine AHA with this ansatz for the electronic binding potential, E(d)=(Eu-Es)Ec-EsEu-Esd/d0+Es, where Eu, Ec, Es correspond to the energies of the united atom, calibration at d0, and the sum of infinitely separated atoms, respectively. Our model covers the two-dimensional electronic potential energy surface spanned by distances of 0.
View Article and Find Full Text PDFBioData Min
January 2025
Biotechnology Research and Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), National Institute of Biomedical Genomics, Kalyani, West Bengal, India.
Background And Objective: Accurate identification and prioritization of driver-mutations in cancer is critical for effective patient management. Despite the presence of numerous bioinformatic algorithms for estimating mutation pathogenicity, there is significant variation in their assessments. This inconsistency is evident even for well-established cancer driver mutations.
View Article and Find Full Text PDFCNS Neurol Disord Drug Targets
January 2025
Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde, 067000, China.
Background: AD is a demyelinating disease. Myelin damage initiates the pathological process of AD, resulting in abnormal synaptic function and cognitive decline. The myelin sheath formed by oligodendrocytes (OL) is a crucial component of white matter.
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