Do anomalies of handedness exist in children with Fragile-X syndrome?

Laterality

Faculty of Medicine, Queens Medical Centre, Nottingham NG9 2UH, UK.

Published: August 2008

AI Article Synopsis

  • The study assessed hand preference and skill in children with Fragile-X syndrome, Down's Syndrome, and typically developing children, focusing on three specific anomalies of handedness.
  • Results showed no significant differences in left-handedness or ambiguous handedness across the groups, but highlighted a notable difference in preference-skill discordance.
  • In the Fragile-X group, 37% showed right hand preference but had no difference in performance between hands, compared to 13% in Down's Syndrome and 17% in the control group, with implications relating to findings in autism research.

Article Abstract

Hand preference and skill were assessed in 27 children with Fragile-X syndrome, 30 children with Down's Syndrome, and 29 normal developing children. Three separate and specific anomalies of handedness that have been reported in other learning-disordered groups were examined: increased incidence of left-handedness; ambiguous or inconsistent handedness; and preference-skill discordance. The results revealed no difference between the subject groups in the distribution of left-handedness or ambiguous handedness. The main differences was the percentage of children who were discordant for hand preference and hand skill. In the Fragile-X group 37% preferred to use their right hand but demonstrated no overall difference in skilled performance between the hands. In contrast, only 13% of children with Down's Syndrome and 17% of normal controls showed this pattern of hand discordance. The results are discussed in the context of past research that has shown a similar dissociation of preference and skill in children with autism.

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http://dx.doi.org/10.1080/713754261DOI Listing

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