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A pregnant woman in her late 20s with a history of epilepsy since childhood presented with recurrent loss of consciousness and witnessed twitching and involuntary muscle contractions. She had hyperemesis during pregnancy reporting four previous miscarriages attributed to seizures. During evaluation in cardiac telemetry and while suffering from severe nausea, the patient experienced prolonged ventricular asystole resulting in convulsive syncope and was diagnosed with cardioinhibitory malignant vasovagal syncope (CMVS).

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Cannabinoid Hyperemesis Syndrome Presumed Secondary to CBD Use: A Case Report.

J Addict Med

September 2024

From the Nantes Université, CHU Nantes, Centre d'Évaluationet d'Information sur la Pharmacodépendance-Addictovigilance (CEIP-A), Service de Pharmacologie Clinique, F-44000 Nantes, France (EL, LS, MD, E-JL, CV-V); and Nantes Université, Univ Tours, CHU Nantes, CHU Tours, INSERM, MethodS in Patients-centered outcomes and HEalth Research, SPHERE, F-44000 Nantes, France (E-JL, CV-V).

Article Synopsis
  • Cannabinoid hyperemesis syndrome involves severe nausea and vomiting linked to heavy cannabis use, raising concerns about cannabidiol (CBD) as a potential trigger due to its rising popularity in legalized areas.
  • A case study of a 32-year-old male who switched from cannabis to CBD revealed recurrent vomiting episodes related to CBD use, despite no cannabis consumption; hot showers temporarily alleviated symptoms.
  • Current hypotheses about the cause of cannabis-induced cyclic vomiting suggest possible mechanisms involving THC accumulation or CBD's effects on specific receptors, highlighting the need for further research into CBD's health impacts.
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This case report details a novel case of Wernicke encephalopathy (WE) in a 16-year-old boy with obesity and chronic cannabis use. Despite the absence of alcohol use disorder, this adolescent developed classic symptoms of WE, challenging the conventional diagnostic framework. Clinical suspicion for WE was supported by typical magnetic resonance imaging findings, low thiamine levels and rapid clinical improvement postintravenous thiamine supplementation.

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Article Synopsis
  • Nausea and vomiting are very common in pregnant women, but only a few get a serious condition called hyperemesis gravidarum (HG), which means they vomit a lot before the 22nd week.
  • HG can lead to dangerous health problems, including a serious issue called pulmonary embolism (PE), which blocks blood flow in the lungs.
  • The case describes a 26-year-old pregnant woman who had HG and developed PE but recovered well after hospital treatment, which included medicine and support for her breathing.
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Marchiafava-Bignami disease (MBD) is uncommon and typically linked with persistent alcohol consumption; nevertheless, instances have been reported in non-alcoholic individuals with nutritional deficiencies. Depending on the severity, this condition may manifest as acute, subacute, or chronic neurological signs and symptoms, ranging from moderate dysarthria or mild disorientation to coma and death. We report a case of a 30-year-old, 14-week pregnant female who presented with complaints of persistent vomiting and loss of appetite.

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