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Pembrolizumab added to neoadjuvant chemotherapy may improve pathological complete response in androgen-receptor positive and low tumor-infiltrating lymphocytes triple-negative breast cancer patients.
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Department of Gynaecological Oncology, Poznań University Clinical Hospital, Szamarzewskiego 84, Poznań, Poland.
Background: Olaparib is a relatively new poly(ADP-ribose) polymerase inhibitor (PARPi) administered to ovarian cancer (OC) patients with a complete or partial response to first-line chemotherapy. One of the metabolic side effects of olaparib is the disruption of glucose homeostasis, often resulting in hyperglycemia The study was a retrospective analysis of olaparib-induced hyperglycemia in OC patients with initial normoglycemia following the first, second, and third month of olaparib treatment METHODS: The study involved 32 OC patients, classified into three groups according to their Body Mass Index (BMI): normal BMI (BMI 18.5-24.
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View Article and Find Full Text PDFPerformance of four thermophilic bacteria for primary sludge hydrolysis: Sludge disintegration and hydrolase activities.
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Thermophilic bacteria (TB) pretreatment is an efficient and environmentally friendly way for accelerating sludge hydrolysis. In this study, a complete comparison of the hydrolysis performance of Bacillus sp. AT07-1 (X1), Parageobacillus toebii X2 (X2), Geobacillus kaustophilus X3 (X3) and Parageobacillus toebii R-35642 (X4) was performed.
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