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Clinicopathological study and molecular subtyping of muscle-invasive bladder cancer (MIBC) using dual immunohistochemical (IHC) markers.
Diagn Pathol
January 2025
Department of Pathology, Kasturba Medical College, India, Manipal, 576104.
Background: Muscle-invasive bladder carcinomas (MIBCs) exhibit significant heterogeneity, with diverse histopathological features associated with varied prognosis and therapeutic response. Although genomic profiling studies have identified several molecular subtypes of MIBC, two basic molecular subtypes are identified - luminal and basal, differing in biological behaviour and response to treatment. As molecular subtyping is complex, surrogate immunohistochemical (IHC) markers have been used to determine the molecular subtypes with good correlation to genomic profiling.
View Article and Find Full Text PDFMicrobial disintegration of wool: An effective and sustainable approach for keratin extraction.
Int J Biol Macromol
December 2024
Biochemistry and Biotechnology Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research (CSIR), Adyar, Chennai 600020, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Keratin is an important biopolymer used to develop biomaterials for biomedical and industrial applications. Traditional keratin extraction methods involve the removal of surface lipids using organic solvents, detergents, and energy-intensive processes that often compromise the purity of the extracted keratin. In the present study, wool fibers were microbially disintegrated to isolate cortical cells, achieving a maximum yield of 61.
View Article and Find Full Text PDFExpanding the Spectrum of GLI1-rearranged Neoplasms of the Gastrointestinal Tract to Include Monophasic Keratin-positive Epithelial Neoplasms.
Am J Surg Pathol
November 2024
Department of Pathology, University of California, San Francisco, CA.
GLI1-altered tumors form a diverse group occurring in various anatomic locations. In the alimentary tract, the most established are gastroblastoma, a biphasic epithelial-mesenchymal neoplasm of the stomach, and plexiform fibromyxoma, a pure spindle cell neoplasm. The spectrum of GLI1-rearranged gastrointestinal tumors has recently expanded with reports of cases in other parts of the GI tract, some exhibiting gastroblastoma-like features and others being pure mesenchymal neoplasms.
View Article and Find Full Text PDFPredictors of Abnormal MRI Findings in Patients with Asymmetrical Sensorineural Hearing Loss.
Laryngoscope
October 2024
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Article Synopsis
- - The study looked at factors predicting abnormal MRI results in patients with asymmetrical sensorineural hearing loss (ASNHL) by reviewing medical records from a tertiary care hospital from 2019 to 2021.
- - Out of 390 patients, 12.8% had abnormal MRI findings related to their hearing loss, with tumors being the most common cause, specifically in the internal acoustic canal or cerebellopontine angle.
- - A significant predictor identified was a hearing asymmetry of 15 dB at 1000 Hz, which showed strong sensitivity in indicating abnormal MRI results and could guide future referrals for MRI scans.
A case report of primary intrahepatic adeno squamous cell cholangiocarcinoma.
Int J Surg Case Rep
November 2024
Mercy University Hospital, Grenville Place, Cork T12 WE28, Ireland.
Introduction: Hepatocellular carcinoma is the most common form of primary liver cancer. Intrahepatic cholangiocarcinoma and fibrolamellar carcinoma make up most other cases. The vast majority of intrahepatic cholangiocarcinoma's are adenocarcinoma in nature.
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