Purpose: The aim of this study was to evaluate the effectiveness of non-penetrating deep sclerectomy with SK-GEL implant in the patients with pseudoexfoliation glaucoma.
Material And Methods: Non-penetrating deep sclerectomy with SK-GEL implant was performed in 5 eyes of 5 patients aged 65 to 78 (mean age 73 years +/- 5.4). Pseudoexfoliation glaucoma was recognized in all patients. In spite of the intensive pharmacological and laser treatment, sufficient reduction of an intraocular pressure was not obtained. The intraocular pressure before the surgery ranged between 24 and 43.4 mmHg (mean 31 mmHg +/- 7.6). Follow-up period lasted from 36 to 53 days (mean 46 days +/- 7.7).
Results: After the surgery, reduction of the intraocular pressure was observed in all subjects. At the moment of discharge from hospital the intraocular pressure ranged from 12 to 26 mmHg (mean 19.6 mmHg +/- 5.12), and at the last control appointment--from 14 to 16 mmHg (mean 14.9 mmHg +/- 0.72).
Conclusions: Non-penetrating deep sclerectomy with SK-GEL implant can be taken into consideration, while planning glaucoma surgery in the patients with pseudoexfoliation syndrome.
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Indian J Ophthalmol
December 2024
Department of Glaucoma Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu, India.
Purpose: To assess the safety and efficacy of non-penetrating deep sclerectomy (NPDS) in advanced open-angle glaucoma patients.
Design: Retrospective observational study.
Methods: Forty-two eyes of 38 patients with advanced glaucoma who underwent NPDS surgery combined with mitomycin-C with or without phacoemulsification were evaluated for up to 12 months at a tertiary eye care center in South India.
J Clin Med
December 2024
Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland.
: This study aimed to investigate the five-year outcomes of deep sclerectomy (DS) in patients with pseudoexfoliation glaucoma (PEXG) and primary open-angle glaucoma (POAG). : This retrospective, observational, unicentric study analyzed POAG and PEXG patients. Intraocular pressure (IOP), the number of IOP-lowering medications, peripapillary retinal nerve fiber layer (RNFL) thickness, the number of postoperative interventions, surgical success rates, and secondary surgery rates were evaluated at baseline and during follow-up appointments.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Department of Ophtalmology, General Hospital Zadar, Ul. Bože Peričića 5, 23000 Zadar, Croatia.
Long-term use of topical prostaglandins might initiate chronic conjunctival inflammation, leading to poor outcomes of glaucoma surgery. The aim of this study was to evaluate the immunoexpression pattern of HSP70, CTGF, SNAIL, aSMA, cMYB, and HIFa in the conjunctiva, episclera, and deep sclera in patients with glaucoma undergoing deep sclerectomy in order to establish an association between staining intensities and prostaglandin F2 (PGF2) treatment. Double immunofluorescence (HSP70, CTGF, SNAIL, aSMA, cMYB, and HIFa) was performed on conjunctiva, episclera, and deep sclera samples, which were obtained from 23 patients treated with PGF2 and 8 patients without PGF2 treatment.
View Article and Find Full Text PDFVestn Oftalmol
November 2024
Krasnov Research Institute of Eye Diseases, Moscow, Russia.
Purpose: This study assesses the impact of preoperative administration of Oku-Oku eye drops on the severity of conjunctival hyperemia and the risk of hemorrhagic complications in the early postoperative period following glaucoma surgery.
Material And Methods: The study included a group of 30 patients (30 eyes) with uncontrolled primary open-angle glaucoma who underwent non-penetrating deep sclerectomy. The main group included 15 eyes, in which Oku-Oku drops were administered twice - on the day before surgery (upon hospital admission) and immediately before the operation.
Ophthalmol Sci
August 2024
St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.
Purpose: To investigate the use of anterior-segment OCT (AS-OCT) to visualize the aqueous outflow pathway and patency of the scleral flap in glaucoma filtration surgery blebs.
Design: Cross-sectional study.
Subjects: Two hundred five filtering blebs of 112 patients with glaucoma who had undergone trabeculectomy (Trab, n = 97) or deep sclerectomy (DS, n = 108) surgery with/without mitomycin-C (MMC).
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