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Is Weight Loss the Main Driver for A1C Improvement by Glucagon-Like Peptide 1 (GLP-1) Receptor Agonists? A 2.5-Year Analysis in Real-World Clinical Practice.
J Diabetes
January 2025
Joslin Diabetes Center, Affiliated With Harvard Medical School, Boston, Massachusetts, USA.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are established treatment options for type 2 diabetes (T2D). In addition to their glycemic benefit, GLP-1 RAs also induce weight loss by suppressing appetite via hypothalamic pathways. However, it remains unclear whether weight reduction is the primary driver of glycemic improvement.
View Article and Find Full Text PDFDemographic and Experiential Characteristics of Asexual Individuals and Associations with Well-Being.
Arch Sex Behav
January 2025
Department of Psychology, Michigan State University, 316 Physics Rd., East Lansing, MI, 48824, USA.
The visibility and number of people identifying as asexual-those with little to no sexual attraction-have been increasing in recent years. In the current study, we examined variation in experiential and developmental milestones and psychosocial functioning in 1,726 individuals on the asexual spectrum (61.2% women, 15.
View Article and Find Full Text PDFLong-term results of staged management of complex lisfranc and chopart injury: a retrospective cohort study and systematic literature review.
Eur J Trauma Emerg Surg
January 2025
Department of Trauma Surgery, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands.
Purpose: The aim was to assess the long-term functional outcome and quality of life after staged surgical treatment of complex Lisfranc and Chopart injuries in a patient cohort, and to perform a systematic review of the literature.
Methods: A retrospective cohort of all trauma patients with complex Lisfranc and/or Chopart injuries treated at our level 1 trauma center between July 1, 2010, and July 1, 2020 with ≥ 3 years follow-up was analyzed in terms of management, complications, and patient-reported outcomes (American Orthopaedic Foot & Ankle Society midfoot score, AOFAS and Foot Function Index, FFI). A systematic review of the literature (according to PRISMA 2020 guidelines) was performed of studies published between January 2000 to April 2024.
Transient Third-Degree Atrioventricular Block in a Dog with Addisonian Crisis.
Vet Sci
January 2025
Department of Clinics, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 700490 Iasi, Romania.
A 3-year-old spayed male mixed-breed Labrador presented to the Emergency and Critical Care Unit with lethargy, loss of appetite, vomiting, a recent history of presyncopal episodes, and severe exercise intolerance. On admission, the patient had bradycardia, low blood pressure, and mild abdominal pain. Serum biochemistry information revealed severe hyperkalemia, hyponatremia, hypoglycemia, and mildly increased liver and kidney parameters.
View Article and Find Full Text PDFTeachers' and Parents' Assessments of Primary School Children's Intellectual Investment as Predictors of Change in Need for Cognition.
J Intell
January 2025
Department of Psychology, TU Dortmund University, Emil-Figge-Straße 50, 44227 Dortmund, Germany.
The present study investigated whether parents' and teachers' evaluations of children's intellectual investment would predict a change in children's need for cognition (NFC) over one year. An exploratory look at how teachers' evaluations are predicted by a range of factors was also taken. = 565 third-graders (298 girls; = 8.
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