Objectives: To test the safety of the head-up tilt test (HUT) in older adults.
Design: Direct observation and measurements.
Setting: Tests performed in a quiet room with dim lighting in a laboratory setting.
Participants: One thousand ninety-six subjects aged 60 to 74; 873 aged 75 and older.
Measurements: Blood pressure and pulse at baseline for 10 minutes and 70 degrees tilt for maximum of 45 minutes. Subjects with unprovoked HUT had test repeated on a separate day after 800 mg glyceryl trinitrate (GTN).
Results: One thousand four hundred ninety-five drug-free and 474 GTN-provoked HUTs were studied. In those aged 60 to 74, the proportion of hypotensive unprovoked HUT was 16% (27% in those aged > or =75); this was higher with GTN provocation (43% in those aged 60-74, 44% in those aged > or =75; P<.01). Systolic blood pressure decreased during provoked HUT (lowest mean+/-standard deviation=67+/-20 in those aged 60-74, 63+/-24 in those aged > or =75; P<.01). There was one cardiovascular and no neurological complications.
Conclusion: This study included 10 times as many people as previous studies and demonstrates the safety of HUT in older people.
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