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Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming.
Chem Biol Interact
January 2025
College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea. Electronic address:
Prostate cancer, the second leading cause of cancer-related mortality in men, exhibits distinct metabolic reprogramming involving zinc and citrate metabolism. This study investigated whether targeting this unique metabolic profile could offer an effective therapeutic approach. A series of novel oxindole derivatives were synthesized and evaluated for their inhibitory effects on transcription factors (TFs) and antiproliferative activity across various cancer cell lines.
View Article and Find Full Text PDFHome oxygen therapy for Thai preterm infants with bronchopulmonary dysplasia. What are the predictive factors for successful weaning: a 20-year review.
BMC Pediatr
January 2025
Division of Pulmonology, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: Consequences of lung injury and inflammation in preterm infants with bronchopulmonary dysplasia (BPD) contribute to prolonged oxygen requirements. Home oxygen therapy (HOT) is an alternative way of respiratory support in infant with BPD. However, there is no consensus on weaning guidelines.
View Article and Find Full Text PDFSelf-reported frequency of handwashing among pet and non-pet owners in different situations: results of four surveys of the general adult population in Germany.
BMC Public Health
December 2024
Hannover Medical School (MHH), Centre of Public Health, Department of Medical Psychology, Carl-Neuberg-Str. 1, Hannover, 30625, Germany.
Background: Zoonotic diseases are partly associated with pets. However, data is sparse on pet owners' compliance with preventive recommendations. Also, research focuses on self-reports, which are subject to overestimation biases, i.
View Article and Find Full Text PDFGenetic identification of undiagnosed benign ethnic neutropenia in patients receiving clozapine treatment.
Br J Psychiatry
December 2024
Institute of Pharmaceutical Sciences, King's College London, UK; and Pharmacy Department, South London and Maudsley NHS Foundation Trust, London, UK.
Article Synopsis
- Clozapine therapy can lead to agranulocytosis, which requires monitoring of white blood cell counts, and it's crucial to identify benign ethnic neutropenia (BEN) to avoid unnecessary clozapine withdrawal.
- * A study introduced voluntary genetic testing for BEN in a clozapine clinic to determine how many patients had undiagnosed BEN, finding that 24% of participants were newly diagnosed with this condition.
- * Results showed that undiagnosed BEN was common among patients, suggesting that adding genetic testing to regular monitoring could improve clozapine therapy management and enable safe continuation for those with unrecognized BEN.
Development and Preliminary Testing of the Withdrawal Assessment Tool-Alpha 2 Agonist: An Assessment Instrument for Monitoring Iatrogenic Withdrawal Symptoms in Children Receiving an Alpha-2 Agonist.
Pediatr Crit Care Med
January 2025
Department of Family and Community Health; School of Nursing, University of Pennsylvania, Philadelphia, PA.
Objectives: To develop and conduct preliminary testing of the Withdrawal Assessment Tool-Alpha 2 Agonist (WAT-A2A) to monitor dexmedetomidine and clonidine withdrawal symptoms in acutely ill children.
Design: Three-phase instrument development study. Phase 1: retrospective chart review of symptoms exhibited by children with documented dexmedetomidine withdrawal; phase 2: WAT-A2A instrument construction based on phase 1 data; and phase 3: prospective testing of the WAT-A2A in children weaning from alpha 2 agonists (A2As).
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