Cutaneous nocardiosis complicating management of Crohn's disease with infliximab and prednisone.

CMAJ

Department of Medicine, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ont.

Published: October 2004

Infliximab is a chimeric anti-tumour necrosis factor-alpha antibody that is efficacious in treating Crohn's disease. However, its immunomodulatory properties increase susceptibility to opportunistic infections. We present a case of cutaneous Nocardia infection in a patient who was taking infliximab for Crohn's disease. The case illustrates the challenges in the diagnosis and management of this disease and serves as a reminder of the complications associated with the use of immunomodulatory agents.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC526332PMC
http://dx.doi.org/10.1503/cmaj.1040563DOI Listing

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