AI Article Synopsis
- Small-molecule kinase inhibitors, like Gleevec and Iressa, show promise as new treatments for cancer and inflammatory diseases, with several candidates in late-stage trials.
- Urea class inhibitors, first introduced in 1996, are gaining attention in medicinal chemistry due to their effective binding and inhibition of kinases.
- The review highlights recent advancements in the development of urea-based protein kinase inhibitors currently being tested in clinical trials by various pharmaceutical companies.
Article Abstract
With two compounds on the market (Gleevec and Iressa), and a number of drug candidates in late-stage clinical trials, small-molecule kinase inhibitors hold great potential as novel therapies for cancer and inflammatory disorders. Inhibitors from the urea class were first reported in 1996 and have emerged as an important compound class for medicinal chemists due to their unique binding mode and kinase inhibition profile. Currently, five members of this class are undergoing clinical trials, BIRB-796 (Boehringer Ingelheim Pharmaceuticals Inc), BAY-43-9006 (Bayer AG/Onyx Pharmaceuticals Inc), CP-547632 (Pfizer Inc), MLN-518 (Millennium Pharmaceuticals Inc) and KRN-951 (Kirin Brewery Co Ltd). This review focuses on the most recent developments in the discovery of urea-based protein kinase inhibitors.
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