Acute adult epiglottitis is a potentially life threatening infectious and respiratory emergency as it may result in airway obstruction. Endotracheal intubation, if needed, is a highly risky option in this situation and responsible for important morbidity and mortality rate. The option of a pharmaceutical anti-oedematous treatment, in order to avoid the risks involved in the endotracheal route has rarely been described. We here report the case of a 50-year-old man with a serious acute infectious epiglottitis who was treated at home by a Mobile Intensive Care Unit where a treatment of nebulized epinephrine and intravenous steroids was undoubtedly a successful option to the endotracheal route. So that, for adult patients and in the absence of any risk of an imminent respiratory arrest, this anti-oedematous treatment should be considered in order to avoid endotracheal route, an option which should be undertaken in case of complications. Nevertheless, this isolated case study concerning an adult is not transposable to children for which airway obstruction tolerance is lower.
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http://dx.doi.org/10.1016/j.annfar.2004.07.008 | DOI Listing |
Eur Arch Psychiatry Clin Neurosci
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Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden.
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Department of Inorganic, Physical and Colloidal Chemistry, Tashkent Pharmaceutical Institute, Oybek Street 45, Tashkent 100015, Uzbekistan.
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December 2022
INBB-Biostructures and Biosystems National Institute, Viale delle Medaglie d'Oro 305, 00136 Rome, RM, Italy.
Coumarin is an effective treatment for primary lymphoedema, as well as lymphoedema related to breast cancer radiotherapy or surgery. However, its clinical use is limited in several countries due to the possible occurrence of hepatotoxicity, mainly in the form of mild to moderate transaminase elevation. It is worth noting that only a few cases of severe hepatotoxicity have been described in the literature, with no reported cases of liver failure.
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August 2022
College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE.
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View Article and Find Full Text PDFPhytochemistry
June 2022
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy; Centro Interdipartimentale di Ricerca 'Riutilizzo Bio-based degli scarti da matrici agroalimentari' (RIVIVE), University of Palermo, Italy.
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