AI Article Synopsis
- A series of Mannich ketones based on piperazinyl oxazolidinone derivatives were created.
- Their antibacterial effectiveness was tested against different Gram-positive bacteria, including Bacillus subtilis and Staphylococcus aureus.
- One specific compound, labeled as compound 12, demonstrated similar antibacterial strength to linezolid and was more effective than eperezolid.
Article Abstract
A few Mannich ketones of piperazinyl oxazolidinone derivatives have been synthesized and their antibacterial activity in various Gram-positive organisms such as Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis were evaluated by MIC determination. Compound 12 showed comparable activity (MIC) to linezolid and superior to eperezolid.
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| http://dx.doi.org/10.1016/j.ejmech.2004.07.007 | DOI Listing |
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