Determination of the free radical scavenging activity of dihydropyran-2,4-diones.

Bioorg Med Chem Lett

LaSO, Laboratório de Síntese Orgânica, Departamento de Química, CCEN, Universidade Federal de Alagoas, 57.072-970 Maceió, AL, Brazil.

Published: December 2004

The antioxidant activities of four synthetic dihydropyran-2,4-diones have been established through the determination of their abilities to inhibit free radicals using DPPH(*) as the stable radical. Whilst all of the compounds exhibited high inhibition percentages, the most active member of the group was 6-phenyl-dihydropyran-2,4-dione. The antioxidant activity of the dihydropyran-2,4-diones is reported here for the first time and extends our knowledge of the range of valuable biological activities associated with this group of compounds.

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http://dx.doi.org/10.1016/j.bmcl.2004.09.030DOI Listing

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