The examination of 468 children and adolescents estimated frequency and structure of chronic pathology of the pharyngeal ring in long-term exposure to low-dose radiation. Chronic disease of the tonsils and adenoids was detected in 194 children (45.4%). Chronic tonsillitis was diagnosed in 142 (33.3%) examinees. 31.7 and 59.9% cases had compensated and subcompensated disease. Decompensated process took place in 8.5% cases of chronic tonsillitis. Hypertrophy of the palatine tonsils and adenoids was detected in 96 (22.5%) children. High incidence of lymphadenopathy of the neck in combination with chronic tonsillitis and tonsil and adenoid hypertrophy was found. Structure of chronic pathology of the lymphoid pharyngeal ring correlated with internal radiation dose. Comparison of postnatally and antenatally radiated children demonstrated less frequent incidence of affected lymphoid pharyngeal ring in children born before the Chernobyl accident.
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PLoS One
January 2025
Division of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan.
Background: Cancer immune responses are generated in secondary lymphoid organs, such as the lymph nodes and tonsils. In the current study, transcriptional profiles of peritumoral tonsillar tissues (PTTs) from oropharyngeal cancers (OPCs) were assessed and compared with those of inflammatory tonsils and regional lymph nodes (rLNs).
Methods: RNA samples of PTTs and rLNs from 13 OPCs, and 4 inflammatory tonsils were subjected to microarray analysis, and differentially expressed genes (DEGs) identified from 730 nCounter Panel immune-related genes.
Anat Histol Embryol
January 2025
Laboratório de Morfologia e Atividade Física, São Paulo State University, Rio Claro, São Paulo, Brazil.
Collared Peccary (Pecari tajacu, Linnaeus, 1758) is a mammalian Tayassuidae species from tropical to semi-arid areas. The morphological features of the oral cavity in this species were identified and described. Tonsils are secondary lymphoid organs essential for contact with antigens due to food and air intake.
View Article and Find Full Text PDFTransl Cancer Res
November 2024
School of Life Sciences, Jiangsu University, Zhenjiang, China.
Background: Head and neck squamous cell carcinoma (HNSCC) contributes significantly to global health challenges, presenting primarily in the oral cavity, pharynx, nasopharynx, and larynx. HNSCC has a high propensity for lymphatic metastasis. Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin lymphoma, exhibits significant heterogeneity and aggressive behavior, leading to high mortality rates.
View Article and Find Full Text PDFDev Comp Immunol
January 2025
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, 87131, USA. Electronic address:
Understanding the ontogeny of teleost mucosa-associated lymphoid tissues (MALT) is critical for determining the earliest timepoint for effective mucosal vaccination of young fish. Here, we describe the developmental sequence that leads to the formation of an organized MALT structure in rainbow trout, the organized nasopharynx-associated lymphoid tissue (O-NALT). Control rainbow trout were sampled between 340 and 1860 degree days (DD) and routine histology and immunofluorescence staining were used to determine cellular changes in immune cells in the nasal cavity as well as O-NALT formation.
View Article and Find Full Text PDFBMC Oral Health
October 2024
Department of Orthodontics, Xiamen Key Laboratory of Stomotalogical Disease Diagnosis and Treatment, Stomatological Hospital of Xiamen Medical College, Xiamen, 361006, P.R. China.
Background: Age plays an important role in the association between adenotonsillar hypertrophy and craniofacial morphology. This study aimed to analyse the association of adenoid and tonsillar hypertrophy with craniofacial features in different age groups.
Methods: Lateral cephalograms were obtained from 942 patients aged 6-15 years (433 boys, 509 girls).
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