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In Vitro Effect of Estrogen and Progesterone on Cytogenetic Profile of Uterine Leiomyomas.
Int J Mol Sci
December 2024
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 199034 St. Petersburg, Russia.
In the present study, we aimed to investigate intratumoral karyotype diversity as well as the estrogen/progesterone effect on the cytogenetic profile of uterine leiomyomas (ULs). A total of 15 UL samples obtained from 15 patients were cultured in the media supplemented with estrogen and/or progesterone and without adding hormones. Conventional cytogenetic analysis of culture samples revealed clonal chromosomal abnormalities in 11 out of 15 ULs.
View Article and Find Full Text PDF[The role of cytogenetic tests in the diagnosis of malignant hematologic diseases].
Magy Onkol
December 2024
Laboratóriumi Medicina Intézet, Debreceni Egyetem, Általános Orvostudományi Kar, Klinikai Genetikai Tanszék, Debrecen, Hungary.
In malignant hematological diseases, clonal genetic alterations, such as chromosomal aberrations and gene mutations, are responsible for the uncontrolled division of abnormal hemopoietic cells. The detection of clonal variants has not only diagnostic, but also prognostic and therapeutic significance. They enable risk-based differentiated treatment of patients and the use of targeted (genotype-specific) therapies.
View Article and Find Full Text PDFV600E-Mutant Acute Myeloid Leukemia: A Case Series and Literature Review of a Rare Entity.
Genes (Basel)
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Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Although V600E mutations are common in solid tumors and select hematologic neoplasms, they are reported less frequently in myeloid malignancies. Of the cases of V600E-mutant acute myeloid leukemia (AML) that have been described, most display monocytic morphology and concurrent rearrangement. Strikingly, all cases have been associated with poor survival.
View Article and Find Full Text PDFSingle-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.
Nat Genet
December 2024
Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
Article Synopsis
- Chromosomal instability contributes significantly to the diversity within tumors, making it a key factor in tumor growth, particularly in complex karyotype acute myeloid leukemia (CK-AML).
- The study revealed various structural variants, including unique patterns of clonal evolution in CK-AML, with a noteworthy 75% of cases exhibiting multiple subclones that continue to evolve.
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- ETP-ALL is a rare subtype of T-cell acute lymphoblastic leukemia, accounting for 10-13% of cases in children and 5-10% in adults.
- A 55-year-old female patient presented with anemia and health deterioration, leading to the diagnosis of ETP-ALL after various tests indicated significant bone marrow invasion by T lymphoid blasts.
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