Conventional kinesin is a multifunctional motor protein that transports numerous organelles along microtubules. The specificity of kinesin-cargo binding is thought to depend on the type(s) of light chains that a kinesin molecule contains. We have shown previously that different isoforms of kinesin light chains are associated with different types of cargo, mitochondria and membranes of the Golgi complex. Here, we provide evidence that the two light chains present within each kinesin molecule are always of the same type. Further, we demonstrate that kinesin heavy chains interact with nascent light-chain polypeptides on ribosomes. These data suggest that incorporation of the two identical light chains into a single kinesin molecule most likely occurs cotranslationally.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/bi049288l | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Surface Doping to Suppress Iodine Ion Migration for Stable FAPbI Perovskite Quantum Dot Solar Cells.
Small
December 2024
Dalian National Laboratory for Clean Energy, iChEM, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, P. R. China.
Formamidine lead iodide (FAPbI) quantum dots (QDs) have attracted great attention as a new generation of photovoltaic material due to their long carrier diffusion length, benign ambient stability, and light-harvesting ability. However, its large surface area with inherent thermodynamic instability and highly defective ionic termination are still major obstacles to fabricating high-performance devices. Herein, a metallic ion dopant is developed to post-treat FAPbI QDs immediately after their fabrication by using a metal-glutamate salt solution.
View Article and Find Full Text PDFInternational Staging System Status and Trend of Relapse in Multiple Myeloma Cases in a Tertiary Level Health Care.
Mymensingh Med J
January 2025
Dr Md Mahbubul Alam, Junior consultant (Medicine), National Gastroliver Institute and Hospital, Dhaka, Bangladesh; E-mail:
Multiple myeloma (MM) is a haematological neoplasm of mature B-cell lineage origin. It is characterized by abnormal clonal proliferation of plasma cells and presence of monoclonal protein in serum and / or urine. This study was conducted to observe the International Staging System (ISS) status and trends of relapse.
View Article and Find Full Text PDFAmorphous organic-hybrid vanadium oxide for near-barrier-free ultrafast-charging aqueous zinc-ion battery.
Nat Commun
December 2024
Key Laboratory of UV Light-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, Changchun, 130024, China.
Fast-charging metal-ion batteries are essential for advancing energy storage technologies, but their performance is often limited by the high activation energy (E) required for ion diffusion in solids. Addressing this challenge has been particularly difficult for multivalent ions like Zn. Here, we present an amorphous organic-hybrid vanadium oxide (AOH-VO), featuring one-dimensional chains arranged in a disordered structure with atomic/molecular-level pores for promoting hierarchical ion diffusion pathways and reducing Zn interactions with the solid skeleton.
View Article and Find Full Text PDFBreaking the Ice: Hofmeister Effect-Inspired Hydrogen Bond Network Reconstruction in Hydrogel Electrolytes for High-Performance Zinc-Ion Batteries.
Small
December 2024
State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.
Gel electrolytes have emerged as a promising solution for enhancing the performance of zinc-ion batteries (ZIBs), particularly in flexible devices. However, they face challenges such as low-temperature inefficiency, constrained ionic conductivity, and poor mechanical strength. To address these issues, this study presents a novel PAMCD gel electrolyte with tunable freezing point and mechanical properties for ZIBs, blending the high ionic conductivity of polyacrylamide with the anion interaction capability of β-cyclodextrin.
View Article and Find Full Text PDFDisease characteristics and cognitive impairment in multiple sclerosis: A short-term observation is not enough.
Neuro Endocrinol Lett
December 2024
1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Background: Multiple sclerosis (MS) is a disease that affects the central nervous system. One of its manifestations is cognitive impairment (CI), which can negatively affect the quality of life in people with MS (pwMS). This study aimed to investigate the nature of CI in MS and its associations with various disease characteristics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!