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Corneal bee sting injury: a clinical conundrum.
BMJ Case Rep
December 2024
Shantilal Shanghvi Cornea Institute (SSCI), L V Prasad Eye Institute(LVPEI), Kode Venkatadri Chowdary(KVC) Campus, Vijayawada, Andhra Pradesh, India
This study outlines the clinical features and comprehensive management of three cases of corneal injury by a bee sting. The stinger removal was attempted, and in two cases, the stinger was successfully removed. In one case, a portion of the stinger broke and was left in situ without inciting any further inflammation.
View Article and Find Full Text PDFSemi-automation of keratopathy visual acuity grading of corneal events in belantamab mafodotin clinical trials: clinical decision support software.
Front Digit Health
October 2023
Oncology Clinical Development GSK, Collegeville, PA, United States.
Background: Belantamab mafodotin (belamaf) has demonstrated clinically meaningful antimyeloma activity in patients with heavily pretreated multiple myeloma. However, it is highly active against dividing cells, contributing to off-target adverse events, particularly ocular toxicity. Changes in best corrected visual acuity (BCVA) and corneal examination findings are routinely monitored to determine Keratopathy Visual Acuity (KVA) grade to inform belamaf dose modification.
View Article and Find Full Text PDFMultimodal imaging and management of multiple retained corneal bee stingers.
BMJ Case Rep
June 2023
Ophthalmology, All India Institute of Medical Sciences - Rishikesh, Dehradun, Uttarakhand, India.
[Corneal and ocular surface injuries caused by occult foreign bodies].
Zhonghua Yan Ke Za Zhi
December 2022
Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Jinan 250021, China.
The first patient complained of red eye, photophobia, and difficulty in eye-opening of the right eye for 5 months. The second patient complained of grinding pain and difficulty in eye-opening of the left eye for 1 week. The third patient complained of repeated red eye and blurred vision in the left eye for half a year.
View Article and Find Full Text PDFPhenotypic and Transcriptomics Analyses Reveal Underlying Mechanisms in a Mouse Model of Corneal Bee Sting.
Toxins (Basel)
July 2022
Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361102, China.
Corneal bee sting (CBS) is one of the most common ocular traumas and can lead to blindness. The ophthalmic manifestations are caused by direct mechanical effects of bee stings, toxic effects, and host immune responses to bee venom (BV); however, the underlying pathogenesis remains unclear. Clinically, topical steroids and antibiotics are routinely used to treat CBS patients but the specific drug targets are unknown; therefore, it is imperative to study the pathological characteristics, injury mechanisms, and therapeutic targets involved in CBS.
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