AI Article Synopsis
- The PDGF family of growth factors helps stabilize blood vessel networks and has been found to promote lymphatic vessel formation in tumors.
- PDGF-BB can increase tumor growth and spread without relying on VEGFR-3, contributing to lymphangiogenesis.
- Targeting the PDGF/PDGF-receptor pathway could be an effective new approach to prevent both blood and lymphatic vessel formation in tumors, potentially slowing down cancer progression.
Article Abstract
The platelet-derived growth factor (PDGF) family of growth factors, which primarily serves the function of stabilizing vascular networks, has now been shown to play a role in promoting tumor lymphangiogenesis. PDGF-BB, independent of VEGFR-3 signaling, induces tumor growth and metastasis in part through supporting lymphangiogenesis. These data suggest that targeting the PDGF/PDGF-receptor signaling pathway will provide a novel strategy to block tumor neoangiogenesis and lymphangiogenesis, thereby inhibiting tumor growth and metastasis.
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| http://dx.doi.org/10.1016/j.ccr.2004.09.024 | DOI Listing |
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