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Joint Effects of Lifestyle Habits and Heavy Metals Exposure on Chronic Stress Among U.S. Adults: Insights from NHANES 2017-2018.
J Xenobiot
January 2025
Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.
Background: Chronic stress, characterized by sustained activation of physiological stress response systems, is a key risk factor for numerous health conditions. Allostatic load (AL), a biomarker of cumulative physiological stress, offers a quantitative measure of this burden. Lifestyle habits such as alcohol consumption and smoking, alongside environmental exposures to toxic metals like lead, cadmium, and mercury, were individually implicated in increasing AL.
View Article and Find Full Text PDFInsights into Landscape Structure Change in Urbanising Rainforest and Guinea Savanna Ecological Regions of Nigeria.
Environ Manage
January 2025
Department of Geoecology, Institute of Geosciences and Geography, Martin Luther University, Halle-Wittenberg, Halle (Saale), Germany.
In the face of unabated urban expansion, understanding the intrinsic characteristics of landscape structure is pertinent to preserving ecological diversity and managing the supply of ecosystem services. This study integrates machine-learning-based geospatial and landscape ecological techniques to assess the dynamics of landscape structure in cities of the rainforest (Akure and Owerri) and Guinea savanna (Makurdi and Minna) ecological regions of Nigeria between 1986 and 2022. Supervised classification using the random forest (RF) machine-learning classifier was performed on Landsat images on the Google Earth Engine (GEE) platform, and landscape metrics were calculated with FRAGSTATS to assess landscape composition, configuration, and connectivity.
View Article and Find Full Text PDFMachine learning-based identification of proteomic markers in colorectal cancer using UK Biobank data.
Front Oncol
January 2025
College of Medicine and Health, School of Medical Sciences, Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
Colorectal cancer is one of the leading causes of cancer-related mortality in the world. Incidence and mortality are predicted to rise globally during the next several decades. When detected early, colorectal cancer is treatable with surgery and medications.
View Article and Find Full Text PDFDengue dynamics, predictions, and future increase under changing monsoon climate in India.
Sci Rep
January 2025
Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.
The global burden of dengue disease is escalating under the influence of climate change, with India contributing a third of the total. The non-linearity and regional heterogeneity inherent in the climate-dengue relationship and the lack of consistent data makes it difficult to make useful predictions for effective disease prevention. The current study investigates these non-linear climate-dengue links in Pune, a dengue hotspot region in India with a monsoonal climate and presents a model framework for predicting both the near-term and future dengue mortalities.
View Article and Find Full Text PDFIdentification of circadian rhythm-related biomarkers and development of diagnostic models for Crohn's disease using machine learning algorithms.
Comput Methods Biomech Biomed Engin
January 2025
Department of Gastroenterolgy, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.
The global rise in Crohn's Disease (CD) incidence has intensified diagnostic challenges. This study identified circadian rhythm-related biomarkers for CD using datasets from the GEO database. Differentially expressed genes underwent Weighted Gene Co-Expression Network Analysis, with 49 hub genes intersected from GeneCards data.
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