We examined the psychometric properties of the Assessment of Depression Inventory (ADI). This instrument assesses depression and also has validity scales that address response honesty. Three studies were conducted. The first describes the development of the ADI. The second compared the concurrent validity of the ADI Depression (Dep) scale with the BDI-II, and the ADI Feigning (Fg) scale responses of psychiatric inpatients with those of a sample of community volunteers asked to feign depression. The third study was used to cross-validate the results with a separate sample of participants. The ADI Dep scale correlated highly with the BDI-II. Significant differences were also found between the honest patient responders and the non-patient feigners on the Fg scale. The data supports the ADI validity scales as measures of response style and the Dep scale as a measure of depression.
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Sci Total Environ
February 2025
695 Park Avenue, The Institute for Sustainable Cities, Hunter College of the City University of New York, New York, NY 10065, United States of America. Electronic address:
Natural organic matter (NOM) in rivers is an important energy source to sustain aquatic ecosystem health. However, in surface water supply systems where chlorination is often used for disinfection, NOM is also a precursor for the carcinogenic and mutagenic disinfection byproducts such as trihalomethanes and haloacetic acids. Effective management of NOM in rivers to maintain both aquatic ecosystem functions and high-quality water supply requires better understanding of the NOM transport patterns.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Qassim University, Buraydah, Saudi Arabia.
Background: In dentistry, local anesthetic is frequently used to manage pain throughout several phases of dental treatments, including tooth extraction. The study aimed to compare the effectiveness of two techniques for controlling pain during mandibular exodontia (tooth extraction), specifically focusing on the pain experienced during injection and extraction of mandibular anterior and premolars teeth. The two techniques being compared are the intraligamentary injection technique (ILI) and the incisive nerve block technique (INB).
View Article and Find Full Text PDFJ Neurol
January 2025
Division of Child Neurology, Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: The presented study identified the appropriate ocrelizumab dosing regimen for patients with pediatric-onset multiple sclerosis (POMS).
Methods: Patients with POMS aged 10-17 years were enrolled into cohort 1 (body weight [BW] < 40 kg, ocrelizumab 300 mg) and cohort 2 (BW ≥ 40 kg, ocrelizumab 600 mg) during a 24-week dose-exploration period (DEP), followed by an optional ocrelizumab (given every 24 weeks) extension period.
Primary Endpoints: pharmacokinetics, pharmacodynamics (CD19 B-cell count); secondary endpoint: safety; exploratory endpoints: MRI activity, protocol-defined relapses, Expanded Disability Status Scale (EDSS) score change.
J Chem Inf Model
January 2025
CEITEC─Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
All-atom molecular dynamics simulations are powerful tools for studying cell membranes and their interactions with proteins and other molecules. However, these processes occur on time scales determined by the diffusion rate of phospholipids, which are challenging to achieve in all-atom models. Here, we present a new all-atom model that accelerates lipid diffusion by splitting phospholipid molecules into head and tail groups.
View Article and Find Full Text PDFSci Adv
January 2025
Department of Chemical and Environmental Engineering, Yale University, New Haven, CT, USA.
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