Objective: To screen the genes that may play an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC).
Methods: Microdissection and cDNA genechip hybridization techniques were used to examine the differentially expressed genes in NPC tissue, the surrounding and adjacent tissues of NPC, and the nasopharyngeal inflammation tissue. The fluorescent signals on cDNA chip were scanned and the results of hybridization analyzed by image processing software.
Results: Many differentially expressed genes were identified between the three samples, including many different types of genes, such as those responsible for signal and protein transmission, oncogene and tumor suppression genes, immune-associated genes, apoptosis genes and DNA binding and transcription factor genes.
Conclusion: The carcinogenesis of NPC involves many genes of a variety of types, suggesting its complex process.
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