AI Article Synopsis
- The study assessed left ventricular diastolic function using mitral annulus velocities in hypertensive patients compared to healthy subjects, revealing significant differences in TDI parameters.
- Patients with left ventricular hypertrophy (LVH) showed lower E(m) and higher A(m), indicating compromised diastolic function, with TDI E(m)/A(m) ratio proving more effective at distinguishing abnormalities than the E/A ratio.
- After one year on antihypertensive treatment, LV mass decreased, and TDI parameters improved, suggesting potential for TDI analysis in early diagnosis and monitoring of treatment efficacy, while highlighting the need for more research on different medication effects.
Article Abstract
The mitral annulus velocities of Doppler transmitral flow and pulsed-wave tissue Doppler imaging (TDI) were sampled by echocardiography for the assessment of left ventricular (LV) diastolic function in 118 never-treated essential hypertensive patients with normal systolic function and compared with those of 59 normotensive healthy subjects matched for age and sex. A selected group (n = 26) of the hypertensive study population was observed after 1 year of pharmacologic antihypertensive treatment to determine the behavior of TDI parameters in relation to eventual regression of LV hypertrophy (LVH). We found that the TDI early myocardial diastolic wave (E(m)) was significantly lower both in concentric and eccentric LVH. In addition, TDI late myocardial diastolic wave (A(m)) was significantly higher in concentric remodeling and concentric and eccentric hypertrophy. The TDI E(m)/A(m) ratio was significantly lower in all geometric remodeling subgroups. The E/A ratio Doppler transmitral flow velocity measured showed that of the 118 patients, only 32 (25%) could really be discriminated from normal, whereas individual analysis for TDI E(m)/A(m) at the mitral annulus septal level showed that of 118 patients 108 (91%) could be discriminated from normal P < .001). The LV mass was significantly less after 1 year of treatment (LVH regression), and TDI parameters showed a trend toward normalization, in particular of TDI E(m)/A(m) at the annular septal level. Pulsed-wave TDI analysis could enable not only the early assessment of whether a patient is still in an adaptive or compensatory phase before transition to irreversible damage (pathologic phase) but also the detection of precocious LV global diastolic dysfunction. With regard to this, more extensive randomized studies are needed to evaluate the effect of different pharmacologic treatments (calcium antagonists, beta-blockers, angiotensin I and II inhibitors) on TDI parameters.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.amjhyper.2004.05.026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Stochastic marine ecosystem modeling for statistical interpretation of the uncertainty factors used for the determination of tolerable daily intake of polychlorinated biphenyls.
Environ Pollut
December 2024
Department of Systems Design for Ocean-Space, Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya, Yokohama, Kanagawa, 2408501, Japan. Electronic address:
This study developed a numerical simulation model for a marine ecosystem to determine accumulation levels of polychlorinated biphenyls (PCBs) in top predators (seabasses). The simulated results were used for calculating probabilities of exceeding tolerable daily intake (TDI) of seafoods enforced by the US and Japanese governments. The model was applied to Tokyo Bay, Japan.
View Article and Find Full Text PDFLeft atrial volumetric/mechanical coupling index and atrial fibrillation in the embolic stroke of undetermined source.
J Cardiovasc Med (Hagerstown)
January 2025
Division of Cardiology, Cardio-Thoracic Department.
Introduction: Nowadays, no clear predictors of atrial fibrillation in patients with embolic stroke of undetermined source (ESUS) are known. Some echocardiographic parameters have been proposed as potential predictors of atrial fibrillation in patients with ESUS. The ratio between left atrial volume and tissue Doppler (TDI) a' provides the left atrial volumetric/mechanical coupling index (LACI) and represents a feasible surrogate for left atrial function, and might be useful to identify atrial fibrillation in this subset of patients.
View Article and Find Full Text PDFAnthracycline-Induced Subclinical Right Ventricular Dysfunction in Breast Cancer Patients: A Systematic Review and Meta-Analysis.
Cancers (Basel)
November 2024
Cardioncology Unit, Cardioncology and Second Opinion Division, European Institute of Oncology, I.R.C.C.S., 20141 Milan, Italy.
Aim: This meta-analysis aims to evaluate the impact of anthracycline chemotherapy on subclinical right ventricular (RV) dysfunction in breast cancer patients, using traditional echocardiographic parameters and strain-based measures, such as the RV global longitudinal strain (RV GLS) and the RV free-wall longitudinal strain (RV FWLS).
Methods And Results: A systematic search was conducted according to PRISMA guidelines, including 15 studies with a total of 1148 breast cancer patients undergoing anthracycline chemotherapy. The primary outcome was the evaluation of changes in RV GLS and RV FWLS pre- and post-chemotherapy.
The Significance of the Myocardial Performance Index and Fetal Doppler Abnormalities in Growth-Restricted Fetuses: A Systematic Review of the Literature.
J Clin Med
October 2024
Department of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, Cegłowska St. 80, 01-809 Warsaw, Poland.
This review aims to investigate the clinical implications of using the myocardial performance index (MPI), obtained through tissue Doppler imaging (TDI) and spectral Doppler, in assessing fetal cardiac function in growth-restricted fetuses. It explores the MPI's potential in predicting adverse perinatal outcomes and its utility when combined with conventional pulsed-wave Doppler assessments for enhanced fetal well-being evaluations. A systematic search of PubMed and Google Scholar databases spanning from 2004 to 2023 was conducted to identify pertinent articles on the MPI's clinical application in managing growth-restricted fetuses.
View Article and Find Full Text PDFHeart Rate Recovery Index and Improved Diastolic Dyssynchrony in Fusion Pacing Cardiac Resynchronization Therapy.
J Clin Med
October 2024
Department of Cardiology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Restoring electrical synchrony with cardiac resynchronization therapy (CRT) reverses the heart failure phenotype developed by left-ventricular (LV) dyssynchrony. This study aimed to identify new predictors of response to LV-only fusion pacing CRT. A select group of patients with CRT-P indications received a right atrium (RA)/LV DDD pacing system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!