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Subchondral insufficiency fracture of the knee.
Orthopadie (Heidelb)
January 2025
Department of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA.
Subchondral insufficiency fractures of the knee (SIFK) are a relatively common cause of knee pain, particularly in middle-aged and older adults. The SIFK is a type of stress fracture that occurs when excessive and repetitive or supraphysiologic loads are applied to subchondral bone [1]. Historically, this type of fracture was termed spontaneous osteonecrosis of the knee (SONK) until advances in MRI identified underlying fractures as well as meniscal deficiency as likely attributable etiologies.
View Article and Find Full Text PDFDual-target nanotherapy for vascular endothelium and bone mesenchymal stem cells halt steroid-induced osteonecrosis of the femoral head progression.
J Control Release
January 2025
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
Steroid-induced osteonecrosis of the femoral head (SANFH) is a common hip joint disease that imposes a heavy economic burden on society. Patients continue to experience bone necrosis even after discontinuing glucocorticoid therapy, and the specific mechanisms require further investigation. The results of this study demonstrate that exosomes secreted by damaged vascular endothelial cells in SANFH lesions may be a crucial factor leading to abnormal adipogenic differentiation of bone marrow stromal cells (BMSCs).
View Article and Find Full Text PDFHistopathological evaluation of spontaneous osteonecrosis of the knee: time to reconsider history and nomenclature-a scoping review.
Musculoskelet Surg
December 2024
Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128, Rome, Italy.
Spontaneous osteonecrosis of the knee (SONK) was first described by Ahlbäck et al. in 1968. However, subsequent studies revealed that subchondral fractures, rather than necrosis, are the most common histopathological finding in bone samples from patients diagnosed with SONK.
View Article and Find Full Text PDFOsteonecrosis of the jaw in patients with clear cell renal cell carcinoma treated with targeted agents: a case series and large-scale pharmacovigilance analysis.
Front Pharmacol
October 2024
Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Objective: To optimize the use of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) for cancer patients, we characterized and evaluated ONJ related to TKIs and ICIs by analyzing a public database and reviewing the relevant literature. TKIs and ICIs are limited to drugs that treat renal cancer recommended by the National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology for Kidney Cancer.
Methods: We described a case series of patients experiencing ONJ while on TKIs or ICIs.
Unicompartmental Knee Arthroplasty Versus Opening-Wedge High Tibial Osteotomy for Spontaneous Osteonecrosis of the Knee: A Retrospective Cohort Study.
Orthop J Sports Med
November 2024
Department of Orthopaedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, Republic of China.
Background: Unicompartmental knee arthroplasty (UKA) and high tibial osteotomy (HTO) are treatment options for patients with medial spontaneous osteonecrosis of the knee (SONK).
Purpose: To compare the clinical outcomes after UKA and HTO in patients with SONK.
Study Design: Cohort study; Level of evidence, 3.
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