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Improved visualization of the inferior tympanic and mastoid canaliculi with photon counting detector CT.
Am J Otolaryngol
December 2024
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Purpose: To compare the performance of the photon-counting detector (PCD)-CT versus a state-of-the-art energy-integrating detector (EID)-CT to identify segments of the inferior tympanic canaliculus (Jacobsons nerve) and the mastoid canaliculus (Arnolds nerve).
Materials & Methods: Patients were prospectively recruited to undergo temporal bone CT on both EID-CT (Siemens Somatom Force) and PCD-CT (Siemens NAEOTOM Alpha) scanners under an IRB-approved protocol. Three neuroradiologists reviewed cases by consensus comparing the ability to identify the proximal, mid, and distal segments of the inferior tympanic canaliculus/Jacobsons nerve and mastoid canaliculus/Arnolds nerve on each scanner using 5-point Likert scales (with 1 indicating EID is far superior to PCD, 3 indicating they are equivalent, and 5 indicating PCD is far superior to EID).
Investigation of the correlation between AGRN expression and perineural invasion in colon cancer.
Front Mol Biosci
December 2024
Department of Colorectal and Anal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China.
Article Synopsis
- Colon cancer, traditionally understood through direct spread and standard metastasis methods, is seeing increased focus on the role of perineural invasion (PNI) in its progression, though research on PNI mechanisms and biomarkers remains limited.
- The study used bioinformatics to identify genes associated with PNI in colon cancer, specifically analyzing AGRN, which was linked to tumor growth and invasion through gene enrichment analysis.
- Results showed that AGRN is overexpressed in colon cancer with PNI and correlates with poorer patient outcomes, suggesting it plays a critical role in PNI development and progression by enhancing both tumor and neural cell activity.*
Perineural spread evaluation of cranial nerves in nasopharyngeal carcinoma: superiority and reliability of isovolumetric MR imaging.
Front Oncol
November 2024
Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Purpose: The purpose of this study was to investigate the advantage of three-dimensional liver acquisition with volume acceleration-flexible (3D LAVA_Flex) for perineural spread (PNS) status of nasopharyngeal carcinoma (NPC) in comparison with two-dimensional magnetic resonance sequences.
Materials And Methods: Sixty pathological proved NPC patients were prospective enrolled. A protocol included T2-weighted imaging with fat suppression (T2WI fs), T1-weighted imaging (T1WI) without and with contrast enhancement (T1WI ce), and 3D LAVA_Flex was applied for the recruited subject.
A rare case of an aggressive polymorphous adenocarcinoma of minor salivary gland in the retro-maxilla.
J Oral Maxillofac Pathol
October 2024
Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, India.
Polymorphous adenocarcinoma (PAC) is a low-grade malignant tumour of minor salivary glands of the oral cavity, which rarely presents with invasive features. Low metastatic and excellent survival rates are some of its favorable features. A 36-year-old woman reported with swelling, pain, and mobility of teeth in the left upper inner cheek region.
View Article and Find Full Text PDFCommentary: "Brachial plexopathy due to perineural tumor spread: a retrospective single-center experience of clinical manifestations, diagnosis, treatments, and outcomes".
Acta Neurochir (Wien)
December 2024
, Rochester, MN, USA.
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