A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity. The key fragments were 2a-c, 5c, 12b, 13b, 17, and 18 which were prepared via dianion ring cyclization, Friedel-Crafts acylation, and Reformatsky reaction. Compound 20b showed the most potent antitumor activity among the total 12 derivatives and compounds 19a and 19b exhibited efficacy comparable to etoposide in vitro antitumor activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2004.09.009 | DOI Listing |
Publication Analysis
Top Keywords
antitumor activity
16
4-hydroxycoumarin derivatives
8
synthesis antitumor
4
activity
4
activity 4-hydroxycoumarin
4
derivatives series
4
series 4-hydroxycoumarin
4
derivatives prepared
4
prepared evaluated
4
evaluated antitumor
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!