Objective: To assess plasma renin activity in a patient with severe ovarian hyperstimulation syndrome (OHSS) and internal jugular vein thrombosis.

Design: Case report.

Setting: University-affiliated infertility center.

Patient(s): A 33-year-old woman with OHSS and internal jugular vein thrombosis.

Intervention(s): Controlled ovulation hyperstimulation with recombinant FSH induction.

Main Outcome Measure(s): Plasma renin activity (PRA), color Doppler ultrasound of the neck.

Result(s): The patient had internal jugular vein thrombosis caused by severe OHSS. The PRA was significantly elevated during the acute stage and subsequently declined after resolution of the OHSS.

Conclusion(s): In this patient elevated PRA appeared to be associated with the development of OHSS and thrombosis. The implication of the ovarian renin-angiotensin system in the development of OHSS and thrombosis is relevant.

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http://dx.doi.org/10.1016/j.fertnstert.2004.02.142DOI Listing

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