Objective: To summarize the existing experience with the use and success rate of assisted reproductive techniques (ART), in particular testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI), in Klinefelter patients.
Design: A systematic review of the literature, including all published case reports to date.
Patient(s): Thirty-nine reported successful pregnancies fathered by nonmosaic Klinefelter patients.
Main Outcome Measure(s): The overall risk of transmitting a chromosomal abnormality to the offspring of Klinefelter patients.
Result(s): In nonmosaic and mosaic Klinefelter patients, chromosomally normal sperm cells can be extracted from testicular tissue and used for ICSI.
Conclusion(s): The application of ART to Klinefelter patients can be recommended as a method to achieve reproduction in this selected infertility patient cohort.
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| http://dx.doi.org/10.1016/j.fertnstert.2003.09.085 | DOI Listing |
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