Objectives: This study describes the clinical, epidemiological and microbiological characteristics of adult patients with blood cancer and neutropenic enterocolitis treated in the Instituto Nacional de Cancerologia (National Cancer Institute) in Bogota, Colombia.
Methods: The clinical histories of 692 adult patients hospitalized in the Instituto Nacional de Cancerologia between 1997 and 2001 with a diagnosis of leukemia or lymphoma were reviewed. Thirty-five of these cases met the criteria for probable or confirmed neutropenic enterocolitis.
Results: Twenty-two cases were confirmed and the remaining 13 were probable neutropenic enterocolitis. All patients were undergoing chemotherapy and all presented watery diarrhea and abdominal pain. In addition, 17% had melena and 25% severe vomiting. Eight of 26 stool cultures (30%) and 17 of 32 (58%) blood cultures were positive for potentially pathogenic microorganisms, particularly gram-negative bacilli. Three patients with probable neutropenic enterocolitis and ten confirmed cases died (37%); mortality was higher among patients who were managed surgically.
Conclusion: Neutropenic colitis presents as a multifactorial syndrome in patients with blood cancer undergoing cytotoxic therapy with agents such as cytosine arabinoside, etoposide, vincristine, cyclophosphamide and corticoids. This highly lethal complication is partly due to infections caused by gram-negative bacilli.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1157/13066853 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Graft-versus-host disease-like gastroenteritis after autologous stem cell transplantation with busulfan/thiotepa conditioning for primary central nervous system lymphoma].
Rinsho Ketsueki
January 2025
Department of Hematology, Graduate School of Medicine, Kyoto University.
Graft-versus-host disease (GVHD) is less common in autologous stem cell transplantation (ASCT) recipients than in allogeneic SCT recipients. However, some cases of severe GVHD, especially involving the gastrointestinal (GI) tract, have been documented. We present a patient with primary central nervous system lymphoma (PCNSL) exhibiting severe GI-GVHD after ASCT with busulfan/thiotepa conditioning.
View Article and Find Full Text PDFPrimary Esophageal Rhabdomyosarcoma: An Exceptionally Rare Cause of Pediatric Dysphagia.
Case Rep Gastrointest Med
December 2024
Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Esophageal embryonal rhabdomyosarcoma (ERMS), a rare pediatric cancer, mimicked achalasia in a case involving dysphagia and vomiting. Diagnosis and chemotherapy necessitate careful monitoring due to potential complications. A 12-year-old girl with no prior medical history presented with progressive dysphagia and vomiting.
View Article and Find Full Text PDFChemotherapy-Induced Jejunal Perforations as an Atypical Presentation of Neutropenic Enterocolitis in an Acute Leukemia Patient.
Cureus
October 2024
Department of Pathology, College of Medicine, Qatar University, Doha, QAT.
Neutropenic enterocolitis (NE) is a potentially life-threatening condition, primarily affecting neutropenic patients with hematologic malignancies. The clinical manifestations of NE in patients receiving antineoplastic drugs range from fever, diarrhea, nausea, vomiting, and abdominal pain to intestinal perforation and shock. We report the case of a 12-year-old boy with acute myelogenous leukemia, undergoing chemotherapy, who presented with an atypical case of NE.
View Article and Find Full Text PDFFatal Neutropenic Enterocolitis in a Young Female After the First Round of Eculizumab for Paroxysmal Nocturnal Hemoglobinuria.
Cureus
September 2024
Internal Medicine, University of Miami at Holy Cross, Fort Lauderdale, USA.
Article Synopsis
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder causing anemia and thrombosis due to a deficiency of specific membrane proteins, which may lead to severe neutropenia and a risk of neutropenic enterocolitis (NEC).
- A case is presented of a 31-year-old woman who developed fatal NEC after receiving eculizumab treatment for PNH, experiencing symptoms like abdominal pain, fever, and worsening neutropenia.
- Despite intensive treatment efforts, she suffered from septic shock and multiple organ failures, ultimately resulting in brain death, illustrating the critical need for early detection and management in patients at high risk for NEC.
A decision analysis of cancer patients and the consumption of ready-to-eat salad.
Risk Anal
October 2024
Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, Michigan, USA.
Article Synopsis
- Listeria monocytogenes poses a heightened risk for cancer patients, leading to more severe health outcomes compared to the general public; the neutropenic diet (ND), which avoids fresh produce, is traditionally used to lower this risk.
- A study developed decision analytic models to evaluate the ND's effects against other dietary practices, finding that the ND resulted in higher rates of neutropenic enterocolitis (NEC) and more negative health impacts overall.
- The results suggest that safer food handling (SFH) practices are more beneficial and less risky than the ND for cancer patients, leading to a recommendation to adopt the SFH diet instead.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!