Although considerable advances in the reduction of global child morbidity and mortality have been made since 1970, when more than 17 million children died, the burden of child mortality is still intolerably high today. An estimated 10.5 million younger than the age of 5 years died in the year 2002 from largely preventable diseases, such as those having infectious, parasitic, and perinatal causes. The reductions in rates of mortality observed did not take place uniformly across time and regions of the world, but the success stories in developing countries demonstrate clearly that low mortality levels are achievable in those settings. If the whole world came to share the current child mortality experience of Northern European countries, more than 10 million deaths of children could be prevented each year. This work aims to answer the questions concerning where and why so many of the world's children still succumb to largely preventable causes.
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http://dx.doi.org/10.1053/j.spid.2004.05.006 | DOI Listing |
Chem Biodivers
January 2025
University of Lille: Universite de Lille, UMR BioEcoAgro, 3 rue du Professeur Laguesse, 59800, LILLE, FRANCE.
Parasitic diseases such as trypanosomiasis and leishmaniasis pose significant health challenges in Africa. The Senegalese Pharmacopoeia, known for its many medicinal plants with anti-infectious properties, can be a source of antiparasitic natural products. This study aimed to evaluate the in vitro antiparasitic activities of 33 methanolic extracts from 24 ethnopharmacologically selected plants against Trypanosoma brucei brucei and Leishmania mexicana mexicana, as well as their cytotoxic activities on WI-38 cells.
View Article and Find Full Text PDFParasitol Res
January 2025
Department of Medical Biology, Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic.
Tick-borne encephalitis virus (TBEV) is flavivirus transmitted to the host via tick saliva which contains various molecules with biological impacts. One of such molecules is Iristatin, a cysteine protease inhibitor from Ixodes ricinus that has been shown to have immunomodulatory properties. To characterize Iristatin in the relation to TBEV, we investigate whether this tick inhibitor has any capacity to influence TBEV infection.
View Article and Find Full Text PDFMicrob Ecol
January 2025
MikroIker Research Group, Immunology, Microbiology and Parasitology Department, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Paseo de La Universidad 7, 01006, Vitoria-Gasteiz, Spain.
The Añana Salt Valley (northern Spain) is a continental saltern consisting of a series of natural springs that have been used for salt production for at least 7000 years. This habitat has been relatively understudied; therefore, prokaryotic diversity was investigated through Illumina-based 16S rRNA gene sequencing to determine if the waters within the valley exhibit distinctive microbiological characteristics. Two main types of water were found in the valley: salty (approximately 200 g/L salinity) from the diapiric structure and brackish (≤ 20 g/L salinity) from shallow streams.
View Article and Find Full Text PDFPLoS One
January 2025
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.
Dengue remains the most rapidly advancing vector-borne disease in the world, and while the disease burden is predominantly in low-to-middle-income countries, the association with poverty remains in question. Consequently, a study was undertaken to evaluate the prevalence of anti-dengue antibodies among individuals residing in the People's Housing Program (PPR), a government-sponsored low-cost housing initiative targeting low-income earners. This type of public housing often faces challenges, including substandard housing facilities.
View Article and Find Full Text PDFActa Crystallogr D Struct Biol
January 2025
Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, 91198 Gif-sur-Yvette, France.
The apicomplexan AP2 (ApiAP2) proteins are the best characterized family of DNA-binding proteins in Plasmodium spp. malaria parasites. Apart from the AP2 DNA-binding domain, there is little sequence similarity between ApiAP2 proteins.
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