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CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds.
Mol Oncol
January 2025
Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
Forkhead box L2 (FOXL2) encodes a transcription factor essential for sex determination, and ovary development and maintenance. Mutations in this gene are implicated in syndromes involving premature ovarian failure and granulosa cell tumors (GCTs). This rare cancer accounts for less than 5% of diagnosed ovarian cancers and is causally associated with the FOXL2 c.
View Article and Find Full Text PDFReprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.
J Nanobiotechnology
December 2024
Cancer Stem Cells and Fibroinflammatory Microenvironment Group, Instituto de Investigaciones Biomédicas (IIBm) Sols-Morreale CSIC-UAM, 28029, Madrid, Spain.
Background: Pancreatic ductal adenocarcinoma (PDAC) requires innovative therapeutic strategies to counteract its progression and metastatic potential. Since the majority of patients are diagnosed with advanced metastatic disease, treatment strategies targeting not only the primary tumor but also metastatic lesions are needed. Tumor-Associated Macrophages (TAMs) have emerged as central players, significantly influencing PDAC progression and metastasis.
View Article and Find Full Text PDFThermoresponsive gel embedding extracellular vesicles from adipose stromal cells improves the healing of colonic anastomoses following irradiation in rats.
Commun Biol
December 2024
Laboratoire de Recherche en Imagerie du Vivant, PARCC, INSERM U970, Université Paris Cité, Paris, France.
Anastomotic leak occurrence is a severe complication after colorectal surgery. Considering the difficulty of treating these leaks and their impact on patient care, there is a strong need for an efficient prevention strategy. We evaluated a combination of extracellular vesicles (EVs) from rat adipose-derived stromal cells with a thermoresponsive gel, Pluronic® F127 (PF-127) to prevent anastomotic leaks.
View Article and Find Full Text PDF[Everyone over the age of 65 years should wear a smartwatch : Pro and contra].
Herzschrittmacherther Elektrophysiol
December 2024
Klinik für Kardiologie II - Rhythmologie, Universitätsklinikum Münster, Albert-Schweitzer-Straße 33, Münster, Deutschland.
Article Synopsis
- Atrial fibrillation (AF) is a common heart rhythm disorder that poses significant risks to patients and healthcare systems.
- The prevalence of AF is projected to double in the next few decades, largely due to an aging population and better detection methods.
- A major concern with AF is the risk of stroke, but at-risk patients can be protected with oral anticoagulants; ongoing discussions focus on the role of wearables for continuous screening in these patients.
[Left bundle branch pacing is superior to classic cardiac resynchronisation therapy : Pros and cons].
Herzschrittmacherther Elektrophysiol
December 2024
Klinik für Kardiologie, Elektrophysiologie und Angiologie, Klinikum Lüdenscheid, Märkische Kliniken GmbH, Lüdenscheid, Deutschland.
Article Synopsis
- Cardiac resynchronisation therapy (CRT) improves quality of life and life expectancy for many heart failure patients, making it a widely used treatment in Germany.
- His bundle pacing and left bundle branch pacing are emerging techniques that show promising success rates and broader applicability.
- The article examines whether left bundle branch pacing is more effective than traditional biventricular pacing, supported by recent studies and guideline recommendations.
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