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Development of a gradual hypoxia chamber for assessing copper toxicity on air-breathing behavior in .
Toxicol Mech Methods
January 2025
Department of Zoology, University of British Columbia, Vancouver, BC, Canada.
Behavioral endpoints are of increasing interest in toxicology because of their sensitivity, but require clear guidance for experimental design. This study describes the design of a hypoxia chamber for use with pond snails, . Studies assessing the switch from water- to air-breathing in hypoxic conditions have previously utilized methods that neglect intricacies of animal behavior such as handling stress and acclimation.
View Article and Find Full Text PDFTAX1BP1 regulates the apoptosis of renal tubular epithelial cells in ischemia/reperfusion injury via the NF-kB/PMAIP1 signaling pathway.
Inflamm Res
January 2025
Department of Nephrology, the Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: The pathogenesis of acute kidney injury (AKI) is not fully understood. Tax1-binding protein 1 (TAX1BP1) modulates inflammation and apoptosis through the NF-kB signaling pathway, however, its specific role in ischemic AKI remains unclear.
Methods: We injected a TAX1BP1 overexpression plasmid into the tail vein of male C57BL/6 mice, followed by clamping the bilateral renal arteries to induce AKI.
Investigating Some Effective Factors on the Prediction of Continuous Positive Airway Pressure Failure Rate in COVID-19-Related Hypoxemia.
Iran J Nurs Midwifery Res
November 2024
Department of Operating Room, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
Article Synopsis
- The study aimed to identify factors influencing CPAP failure rates in patients with COVID-19-related hypoxemia, analyzing 200 ICU patients in southwestern Iran.
- Results showed a high CPAP failure rate (78.5%), particularly linked to higher HACOR scores, diabetes mellitus, older age, obesity, and elevated Blood Urea Nitrogen levels.
- The findings suggest that specific clinical factors such as HACOR scores and comorbidities significantly impact the effectiveness of CPAP therapy in these patients.
The Role of Lactate in Ischemic Stroke: As an Energy Source and Signaling Molecule.
Curr Protein Pept Sci
January 2025
College of Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Stroke is an acute cerebrovascular disease that causes brain tissue damage due to sudden blockage or rupture of blood vessels in the brain. According to the latest data from the Global Burden of Disease Study, the number of stroke patients worldwide is estimated to exceed 100 million, and more than 80% of patients suffer from stroke. Ischemic stroke is a type of stroke due to which two-thirds of the patients are disabled or even die, seriously affecting the patient's quality of life.
View Article and Find Full Text PDFPhosphorylation of a nuclear condensate regulates cohesion and mRNA retention.
Nat Commun
January 2025
Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Nuclear speckles are membraneless organelles that associate with active transcription sites and participate in post-transcriptional mRNA processing. During the cell cycle, nuclear speckles dissolve following phosphorylation of their protein components. Here, we identify the PP1 family as the phosphatases that counteract kinase-mediated dissolution.
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