Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.schres.2004.03.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The potential of cognitive remediation therapy for improving the communication capabilities of adults with schizophrenia and other psychotic spectrum disorders.
Int J Lang Commun Disord
December 2024
Marathon Health, Bathurst, New South Wales, Australia.
Background: Impairment in aspects of communication is a core diagnostic feature of schizophrenia and other psychotic spectrum disorders. These communication difficulties inhibit participation in a range of daily activities and affect relationships and quality of life. There has been little research focussed on communication outcomes in relation to cognitive remediation therapy within this population.
View Article and Find Full Text PDFThe moderating role of COMT gene rs4680 polymorphism between maladaptive metacognitive beliefs and negative symptoms in patients with schizophrenia.
BMC Psychiatry
November 2024
School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, P.O. Box 446, Jounieh, Lebanon.
Background: Although the positive association between impairments in metacognitive capacity and negative symptoms in people with schizophrenia spectrum disorders is widely evidenced in the literature, the explaining mechanisms of this association are still less known and poorly understood. This study aims to bridge this knowledge gap by testing the hypothesis that COMT rs4680 variants will act as moderators in the relationship between certain metacognitive domains and negative symptoms' severity.
Method: A cross-sectional study was carried-out during the period between February and March 2024.
Variations in inflammatory regulators in male patients with chronic schizophrenia associated with psychopathology and cognitive deficits.
BMC Psychiatry
November 2024
Department of Psychiatry, The Fourth People's Hospital of Lianyungang, The Affiliated KangDa College of Nanjing Medical University, No. 316, Jiefangdong Road, Lianyungang, Jiangsu, 222003, PR China.
Background: Immune dysregulation has been identified as a contributing factor in the pathophysiology of schizophrenia. This study aimed to investigate variations in specific immune regulators and their correlation with psychopathology and cognitive functions in male patients with chronic schizophrenia.
Methods: Employing a cross-sectional design, this study included 72 male patients with chronic schizophrenia.
OUTLINING THE ABSENCE: FROM INFLAMMATION TO A DISTINCT ENDOPHENOTYPE FOR THE NEGATIVE SYMPTOMS OF SCHIZOPHRENIA.
Psychiatr Danub
August 2024
Department of Psychiatry, Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
The concept of schizophrenia as a mental condition is subject to deconstruction for a broader approach toward a systemic disorder by encompassing the links with inflammation. Beyond the salient psychotic symptoms of schizophrenia, the negative symptoms remain the silent cause of deterioration and the hallmark of a worse prognosis. Either as part of a unitary disorder or as a distinct subtype of schizophrenia, the negative symptoms seem to be associated with specific biological features.
View Article and Find Full Text PDFEFFECT OF VORTIOXETINE ON THE QUALITY OF LIFE IN PATIENTS WITH SCHIZOPHRENIA.
Psychiatr Danub
May 2024
Department of Psychiatry, University Clinical Centre Vojvodina, Novi Sad, Serbia.
Quality of life is a multidimensional concept that includes both positive and negative aspects of well-being and life, as well as social, psychological and physical health. It is related to health and refers to the optimal level of mental, physical and social functioning.The aim of the research was to examine the effects of vortioxetine on the quality of life in patients with schizophrenia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!